PMID: 11923187Mar 30, 2002Paper

Axon navigation in the mammalian primary olfactory pathway: where to next?

Chemical Senses
Brian Key, James St John

Abstract

The process of establishing long-range neuronal connections can be divided into at least three discrete steps. First, axons need to be stimulated to grow and this growth must be towards appropriate targets. Second, after arriving at their target, axons need to be directed to their topographically appropriate position and in some cases, such as in cortical structures, they must grow radially to reach the correct laminar layer. Third, axons then arborize and form synaptic connections with only a defined subpopulation of potential post-synaptic partners. Attempts to understand these mechanisms in the visual system have been ongoing since pioneer studies in the 1940s highlighted the specificity of neuronal connections in the retino-tectal pathway. These classical systems-based approaches culminated in the 1990s with the discovery that Eph-ephrin repulsive interactions were involved in topographical mapping. In marked contrast, it was the cloning of the odorant receptor family that quickly led to a better understanding of axon targeting in the olfactory system. The last 10 years have seen the olfactory pathway rise in prominence as a model system for axon guidance. Once considered to be experimentally intractable, it is now providin...Continue Reading

Citations

Apr 25, 2012·Brain Structure & Function·Maurizio LazzariValeria Franceschini
Mar 4, 2006·Journal of Molecular Histology·Fatemeh ChehrehasaBrian Key
Dec 24, 2005·Journal of Neurocytology·Adele J VincentMeng Inn Chuah
Mar 2, 2005·Chemical Senses·Richard M Costanzo
Oct 13, 2006·Annual Review of Cell and Developmental Biology·Peter Mombaerts
Mar 30, 2012·Neuro-Signals·Jenny A K EkbergJames A St John
Jul 31, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Helen B TreloarCharles A Greer
Aug 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·David M LinJohn Ngai
Oct 15, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Sara Hayden, Emma C Teeling
Aug 30, 2008·Current Opinion in Neurobiology·Takeshi Imai, Hitoshi Sakano
May 24, 2008·Brain Research Bulletin·George Gomez, Amanda Celii
Aug 31, 2007·European Journal of Cell Biology·Qingyi Zheng-FischhöferKlaus Willecke
Dec 14, 2011·Biotechnology Journal·Birsen DemirbagVasif Hasirci
Oct 30, 2013·Journal of Anatomy·Maurizio LazzariValeria Franceschini
Aug 19, 2007·Brain Research·Fatemeh ChehrehasaJames A St John
Jun 28, 2011·Molecular and Cellular Neurosciences·Katie E LineburgJames A St John
May 14, 2003·Neuron·Peter C Brunjes, Charles A Greer
Jun 3, 2004·The Journal of Comparative Neurology·John A HamlinJames E Schwob
Jun 29, 2004·The Journal of Comparative Neurology·Melonie Joanne StoranBrian Key
Jun 15, 2006·Izvestiia Akademii nauk. Seriia biologicheskaia·A V Markov, A M Kulikov
Aug 31, 2007·The Journal of Comparative Neurology·Sarah A DunlopL D Beazley
Feb 15, 2020·Journal of Neurotrauma·Aaron D GilmourJames A St John
Feb 18, 2003·Development·Lay-Hong AngHuey Hing

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