Axon reaction in dorsal motor vagal and hypoglossal neurons of the adult rat. Light microscopy and RNA-cytochemistry

The Journal of Comparative Neurology
H AldskogiusR Regal

Abstract

Qualitative light microscopical observations, morphometric measurements, and cytophotometric values for nucleolar and cytoplasmic RNA were compared in axotomized rat dorsal motor vagal and hypoglossal neurons. These data were correlated with consective cell counts and examination of the peripheral nerves. Vagal neurons showed an early prominent chromatolysis, later accompanied by increased cytoplasmic basophilia. Morphometric data showed a transient slight cytoplasmic enlargement but no nucleolar hypertrophy. Nucleolar RNA was unchanged, but cytoplasmic RNA was elevated 7 to 84 days postoperatively. Cell counts demonstrated a final cell loss of about 70%. Hypoglossal neurons showed a moderate chromatolysis. Nucleolar and cytoplasmic areas were enlarged for a short period. Nucleolar and cytoplasmic RNA were elevated about 3 to 14 days and about 3 to 28 days postoperatively, respectively. Cell counts demonstrated a loss of 25% at the longest postoperative survival period. The results indicate that axotomized adult mammalian extrinsic neurons--even those destined to die--accumulate RNA. This response contrasts with axon reaction in many axotomized mammalian intrinsic neurons which appear to undergo depletion of RNA.

References

Jul 22, 1977·Brain Research·K D BarronM E Scheibly
Nov 5, 1976·Brain Research·K D BarronM E Scheibly
Feb 1, 1970·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J R Shea
Apr 12, 1972·Nature: New Biology·P R LewisV Navaratnam
Jan 1, 1971·International Review of Neurobiology·A R Lieberman
Jan 1, 1957·Journal of Neurochemistry·S O BRATTGARDH HYDEN
Jan 1, 1958·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R W MERRIAM
Oct 1, 1948·The Journal of Comparative Neurology·M L BARR, J D HAMILTON

❮ Previous
Next ❯

Citations

Dec 1, 1982·Journal of Neurocytology·P M RichardsonS Shemie
Jun 1, 1984·Journal of Neurocytology·L J MisantoneM Murray
Oct 1, 1982·Journal of Neurocytology·K D BarronR Kohberger
Jul 1, 1986·Journal of Neuroscience Methods·R G Wiley, T N Oeltmann
Oct 1, 1983·Journal of the Autonomic Nervous System·T L PowleyH R Berthoud
Jan 1, 1996·Brain Research. Molecular Brain Research·M SarasaJ M Palacios
Jan 1, 1992·Neuroscience·C H Hubscher, K J Berkley
Jul 1, 1985·Brain Research Bulletin·D B HooverT E DePorter
Mar 1, 1987·Brain Research Bulletin·M F GonzalezS M Sagar
Jan 1, 1993·Brain Research Bulletin·M SvenssonH Aldskogius
Jul 17, 2001·Brain Research. Developmental Brain Research·T L PowleyS E Swithers
Apr 13, 1999·Trends in Neurosciences·M KoltzenburgS B McMahon
Feb 4, 2010·Journal of Neurotrauma·Nurettin CengizElif Kaval Oğuz
Feb 5, 2013·Acta Histochemica Et Cytochemica·Naomi J BisemIkuo Tooyama
Apr 22, 1992·The Journal of Comparative Neurology·T BrännströmJ O Kellerth
Oct 1, 1992·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·W F NeissE Stennert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.