PMID: 6969898Oct 1, 1980Paper

Axon reflex in ocular injury: sensory mediation of the response of the rabbit eye to laser irradiation of the iris

Quarterly Journal of Experimental Physiology and Cognate Medical Sciences
J M ButlerD F Cole

Abstract

Laser irradiation of the rabbit iris produces an injury response consisting of prolonged miosis, uveal vasodilation and a transient rise of intraocular pressure (IOP) accompanied by a breakdown of the blood-aqueous barrier. This response has hitherto been attributed partly to prostaglandin (PG) mediation and partly to mediation by a non-cholinergic nervous pathway thought to be sensory in fuction. Responses of the rabbit eye to laser irritation were examined at specified intervals after diathermic coagulation of the epigasserian nerve tract. Both the intensity of the pupillary constriction and the increase in IOP were almost unaltered at 90 minutes but progressively decreased until at 4 days there was essentially no response to high energy laser irradiation in the denervated eye. It was evident that manifestation of the response is largely dependent upon the presence of intact and functional sensory nerves, and it is proposed that endogenous PGs exert some, if not all of their effects via sensory nerve endings. It is suggested that those terminals which are directly stimulated, whether by laser irradiation or by PGs formed during the injury, release some mediator to cause pupillary constriction. From thes terminals impulses pas...Continue Reading

Citations

Mar 1, 1983·American Journal of Ophthalmology·R N WeinrebK Zweig
Jan 1, 1980·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·W G UngerE E Morsi
Aug 1, 1982·Ophthalmology·R M DuffinT H Pettit
Dec 1, 1984·Experimental Eye Research·R N Williams, P Bhattacherjee
Jan 1, 1996·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G R Holland
Jun 1, 1984·European Journal of Pharmacology·G BynkeF Sundler
Apr 30, 1992·Annals of the New York Academy of Sciences·W G Unger
Jan 1, 1990·Journal of Ocular Pharmacology·W G Unger
Oct 1, 1985·The British Journal of Ophthalmology·J FruchtU Ticho
Jan 1, 1991·The British Journal of Ophthalmology·R V Pearson, G E Rose
Apr 1, 1984·The British Journal of Ophthalmology·G van RijJ T Jansen

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