Axon-somatic back-propagation in detailed models of spinal alpha motoneurons

Frontiers in Computational Neuroscience
Pietro BalbiPaolo Massobrio

Abstract

Antidromic action potentials following distal stimulation of motor axons occasionally fail to invade the soma of alpha motoneurons in spinal cord, due to their passing through regions of high non-uniformity. Morphologically detailed conductance-based models of cat spinal alpha motoneurons have been developed, with the aim to reproduce and clarify some aspects of the electrophysiological behavior of the antidromic axon-somatic spike propagation. Fourteen 3D morphologically detailed somata and dendrites of cat spinal alpha motoneurons have been imported from an open-access web-based database of neuronal morphologies, NeuroMorpho.org, and instantiated in neurocomputational models. An axon hillock, an axonal initial segment and a myelinated axon are added to each model. By sweeping the diameter of the axonal initial segment (AIS) and the axon hillock, as well as the maximal conductances of sodium channels at the AIS and at the soma, the developed models are able to show the relationships between different geometric and electrophysiological configurations and the voltage attenuation of the antidromically traveling wave. In particular, a greater than usually admitted sodium conductance at AIS is necessary and sufficient to overcome t...Continue Reading

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Citations

Jul 2, 2016·The Journal of Physiology·S C GandeviaJ L Taylor
Oct 9, 2015·PLoS Biology·Giorgio A Ascoli
Jun 21, 2017·Journal of Neural Engineering·A KuckE H F van Asseldonk
Jun 13, 2018·Journal of Neural Engineering·Guosheng Yi, Warren M Grill
Jul 6, 2018·Journal of Neurophysiology·Bahar MoezziJochen Triesch
Aug 24, 2019·Frontiers in Neuroinformatics·Raghu Sesha IyengarMohan Raghavan

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NEURON
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