PMID: 9427514Jan 14, 1998Paper

Axon-target interactions maintain synaptic gene expression in retinae transplanted to intracranial regions of the rat

Brain Research. Molecular Brain Research
F HooverD Goldman

Abstract

In the present study we examined the effects of optic axon-CNS target interactions on gene expression in the rat retina. These studies took advantage of a transplantation paradigm that allowed us to assay gene expression in retinae transplanted to different intracranial locations in the neonatal rat that either promoted (dorsal midbrain) or precluded (cerebral cortex) the formation of retino-collicular connections. Using in situ hybridization experiments, we observed that transplantation to the dorsal midbrain resulted in a relatively normal pattern of nicotinic acetylcholine receptor (nAChR) beta-3 subunit and glutamate receptor 3 (GluR3) gene expression. In contrast, retinae transplanted to the cerebral cortex (which did not result in normal retino-collicular interactions) showed a dramatic reduction in nAChR beta-3 subunit and GluR3 gene expression. These results agree with those obtained in the adult goldfish retina, where it has been demonstrated that an optic nerve-optic tectum interaction is responsible for the re-induction nAChR and NMDA receptor gene expression during optic nerve regeneration. Taken together, these results support the hypothesis that proper axon-target interactions are required for maintenance of nAChR...Continue Reading

References

May 23, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·V H Perry
Jan 1, 1992·Visual Neuroscience·T E HughesS Heinemann
Feb 25, 1991·Neuroscience Letters·F Gonzalez-Lima, M Garrosa
Oct 8, 1990·The Journal of Comparative Neurology·J D RadelR D Lund
Jul 16, 1990·Brain Research·L S JenW Z Shen
Jan 1, 1987·Annual Review of Neuroscience·S M Schuetze, L W Role
Mar 1, 1989·Trends in Neurosciences·M T Wong-Riley
Mar 22, 1988·The Journal of Comparative Neurology·A J Sefton, R D Lund
Jan 15, 1985·The Journal of Comparative Neurology·V H PerryS C McLoon
Mar 18, 1966·Science·R D Lund, L E Westrum
Apr 1, 1984·Neuroscience·C J Barnstable, U C Dräger
Jan 1, 1980·Experimental Brain Research·S C McLoon, R D Lund
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M T Wong-Riley, C Welt
Jan 1, 1984·Brain Research·S C McLoon, R D Lund
Apr 1, 1994·Neuron·S Cohen-Cory, S E Fraser
Sep 17, 1993·Brain Research. Developmental Brain Research·M HankinR D Lund
Jul 1, 1993·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E Chen
Aug 1, 1993·Journal of Neurobiology·M H HankinD Goldman
Apr 29, 1996·Brain Research·F HooverM H Hankin

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Citations

Nov 19, 2002·Journal of Neurobiology·Madelaine M RosenbergMichele H Jacob
Apr 17, 2014·The Journal of Comparative Neurology·Hong-Ping XuNing Tian

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