Axonal accumulation of hyperpolarization-activated cyclic nucleotide-gated cation channels contributes to mechanical allodynia after peripheral nerve injury in rat

Pain
Yu-Qiu JiangYou Wan

Abstract

Peripheral nerve injury causes neuropathic pain including mechanical allodynia and thermal hyperalgesia due to central and peripheral sensitization. Spontaneous ectopic discharges derived from dorsal root ganglion (DRG) neurons and from the sites of injury are a key factor in the initiation of this sensitization. Numerous studies have focused primarily on DRG neurons; however, the injured axons themselves likely play an equally important role. Previous studies of neuropathic pain rats with spinal nerve ligation (SNL) showed that the hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channel in DRG neuronal bodies is important for the development of neuropathic pain. Here, we investigate the role of the axonal HCN channel in neuropathic pain rats. Using the chronic constriction injury (CCI) model, we found abundant axonal accumulation of HCN channel protein at the injured sites accompanied by a slight decrease in DRG neuronal bodies. The function of these accumulated channels was verified by local application of ZD7288, a specific HCN blocker, which significantly suppressed the ectopic discharges from injured nerve fibers with no effect on impulse conduction. Moreover, mechanical allodynia, but not thermal hyperalg...Continue Reading

References

Jul 1, 1991·British Medical Bulletin·M Devor
Apr 1, 1995·Anesthesiology·J G ThalhammerG R Strichartz
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·S G WaxmanJ A Black
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·F PorrecaJ C Hunter
Oct 31, 2002·Nature Neuroscience·Joachim Scholz, Clifford J Woolf
Dec 10, 2002·Annual Review of Physiology·Richard B Robinson, Steven A Siegelbaum
Oct 25, 2003·Biochemical and Biophysical Research Communications·Ricardo FelixAlberto Darszon
Oct 4, 2006·Neuron·James N Campbell, Richard A Meyer
Oct 17, 2006·The European Journal of Neuroscience·Junichi KitagawaKoichi Iwata
Feb 27, 2007·Brain, Behavior, and Immunity·Wendy Marie Campana

❮ Previous
Next ❯

Citations

Mar 3, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Amteshwar Singh Jaggi, Nirmal Singh
May 22, 2009·Current Pain and Headache Reports·Andrea M Harriott, Michael S Gold
Nov 6, 2010·Archives of Pharmacal Research·Eduardo Gascon, Aziz Moqrich
May 12, 2010·Clinical and Experimental Pharmacology & Physiology·Yu-Hong ZhouJohn H Schild
Sep 10, 2011·Science·Edward C EmeryPeter A McNaughton
Aug 26, 2011·Journal of Neurophysiology·Natalie RichardsAndrew Dilley
Jun 25, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aleksander W BalloDirk Bucher
Apr 24, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aleksander W Ballo, Dirk Bucher
Mar 4, 2014·World Journal of Gastroenterology : WJG·Yu ChenDa-Li Lu
Mar 24, 2011·Future Medicinal Chemistry·Elena ColomboPaolo Pevarello
Jan 13, 2015·International Journal of Molecular Sciences·Stefan HerrmannAndreas Ludwig
Jul 30, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ji-Sheng Han
May 23, 2012·Trends in Pharmacological Sciences·Edward C EmeryPeter A McNaughton
May 15, 2012·Neuroscience Letters·Hiroyuki Nodera, Seward B Rutkove
Jul 12, 2011·European Journal of Pharmacology·Amteshwar Singh Jaggi, Nirmal Singh
Sep 18, 2010·European Journal of Pharmacology·Amteshwar Singh Jaggi, Nirmal Singh
Aug 12, 2009·Journal of the Neurological Sciences·Li HuangHuailian Guo
Aug 25, 2009·Progress in Neurobiology·Arun V KrishnanMatthew C Kiernan
Jan 13, 2016·Anesthesia and Analgesia·Tao HuTao Liu
Jun 10, 2010·The European Journal of Neuroscience·Gary W Wilson, John Garthwaite
Mar 1, 2012·Neuron·Christian A von HehnClifford J Woolf
Sep 16, 2014·Frontiers in Neuroscience·Monica NorciniEsperanza Recio-Pinto
May 29, 2016·Trends in Pharmacological Sciences·Gareth R TibbsPeter A Goldstein

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.