Axonal and nonneuronal cell responses to spinal cord injury in mice lacking glial fibrillary acidic protein

Experimental Neurology
X WangS David

Abstract

We have examined the regeneration of corticospinal tract fibers and expression of various extracellular matrix (ECM) molecules and intermediate filaments [vimentin and glial fibrillary acidic protein (GFAP)] after dorsal hemisection of the spinal cord of adult GFAP-null and wild-type littermate control mice. The expression of these molecules was also examined in the uninjured spinal cord. There was no increase in axon sprouting or long distance regeneration in GFAP-/- mice compared to the wild type. In the uninjured spinal cord (i) GFAP was expressed in the wild type but not the mutant mice, while vimentin was expressed in astrocytes in the white matter of both types of mice; (ii) laminin and fibronectin immunoreactivity was localized to blood vessels and meninges; (iii) tenascin and chondroitin sulfate proteoglycan (CSPG) labeling was detected in astrocytes and the nodes of Ranvier in the white matter; and (iv) in addition, CSPG labeling which was generally less intense in the gray matter of mutant mice. Ten days after hemisection there was a large increase in vimentin+ cells at the lesion site in both groups of mice. These include astrocytes as well as meningeal cells that migrate into the wound. The center of these lesions w...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E D LaywellD A Steindler
Nov 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C K PetitoM L Lesser
Mar 1, 1986·The Journal of Cell Biology·C Ffrench-ConstantM C Raff
Feb 18, 1985·Brain Research·A J Mathewson, M Berry
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Hockfield, R D McKay
Jul 1, 1993·Genes & Development·H BaribaultR G Oshima
Jul 1, 1993·Journal of Neuroscience Research·J TaylorM Schachner
Jun 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K J Green, J C Jones
Jul 1, 1996·Nature Genetics·R van der NeutA Sonnenberg
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A McCallA Messing
Jun 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D R CanningJ Silver

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Citations

Jun 5, 2003·Experimental Neurology·Charles R BuckRobert J McKeon
Dec 11, 2002·The European Journal of Neuroscience·Tânia Cristina Leite de Sampaio e SpohrFlávia Carvalho Alcantara Gomes
Mar 11, 2003·Annual Review of Neuroscience·Samuel David, Steve Lacroix
Jan 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah A BuschJerry Silver
Jun 11, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arsen S HunanyanVictor L Arvanian
Jul 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·V MenetM Giménez y Ribotta
Feb 23, 2010·Experimental Neurology·Julia E HerrmannBinhai Zheng
Oct 21, 2004·The Journal of Pathology·Milos Pekny, Marcela Pekna
Apr 25, 2008·The International Journal of Biochemistry & Cell Biology·Francois Renault-MiharaHideyuki Okano
Mar 29, 2008·Behavioural Brain Research·Olivier Raineteau
May 16, 2015·Trends in Neurosciences·Zhihui Yang, Kevin K W Wang
Apr 14, 2004·The European Journal of Neuroscience·Vivian de Oliveira SousaFlávia Carvalho Alcantara Gomes
Oct 13, 2006·Trends in Neurosciences·Binhai ZhengFang Xie
Feb 11, 2014·Neuroscience Letters·Michael Brenner
May 31, 2014·Molecular Neurobiology·Bao-Jiang QianTing-Hua Wang
Jul 21, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F C GomesV Moura Neto
May 11, 2000·The Journal of Comparative Neurology·F Mercier, G I Hatton
Feb 13, 2001·Journal of Neuroscience Research·J McGrawJ D Steeves
Apr 25, 2000·Journal of Neurotrauma·L B JakemanB T Stokes
Apr 23, 2005·Glia·Milos Pekny, Michael Nilsson
Jul 8, 2003·Nature Neuroscience·Reiko KinouchiDong Feng Chen
Apr 18, 2007·Brain : a Journal of Neurology·Jian ChenMelitta Schachner
Apr 16, 2020·Cell Communication and Signaling : CCS·Yunxiang ZhouJianmin Zhang
Dec 26, 2001·Journal of Neuroscience Research·Hidenobu TanakaNobufumi Kawai
Aug 28, 2021·Biomedicines·Kjeld Morten MohrChristian Bjerggaard Vaegter

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