PMID: 9192287Apr 1, 1997Paper

Axonal cytoskeletal changes after non-disruptive axonal injury

Journal of Neurocytology
S S JafariD I Graham

Abstract

In animal models of human diffuse axonal injury, axonal swellings leading to secondary axotomy occur between 2 and 6 h after injury. But, analysis of cytoskeletal changes associated with secondary axotomy has not been undertaken. We have carried out a quantitative analysis of cytoskeletal changes in a model of diffuse axonal injury 4 h after stretch-injury to adult guinea-pig optic nerves. The major site of axonal damage was the middle portion of the nerve. There was a statistically significant increase in the proportion of small axons with a diameter of 0.5 micron and smaller in which there was compaction of neurofilaments. Axons with a diameter greater than 2.0 microns demonstrated an increased spacing between cytoskeletal elements throughout the length of the nerve. However, in the middle segment of the nerve these larger axons demonstrated two different types of response. Either, where periaxonal spaces occurred, there was a reduction in axonal calibre, compaction of neurofilaments but no change in their number, and a loss of microtubules. Or, where intramyelinic spaces occurred there was an increased spacing between neurofilaments and microtubules with a significant loss in the number of both. Longitudinal sections showed ...Continue Reading

Citations

Jan 1, 1999·Journal of Neurotrauma·K E SaatmanT K McIntosh
Jun 7, 2000·Neuropathology and Applied Neurobiology·J F GeddesD I Graham
Apr 5, 2003·Journal of Neurotrauma·William L MaxwellDavid I Graham
Oct 26, 2012·Journal of Neuropathology and Experimental Neurology·Ann Mae DileonardiRamesh Raghupathi
Sep 11, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Adam J FournierK T Ramesh
Apr 3, 2007·Neurochemical Research·Gulyeter SerbestKathryn E Saatman
Dec 15, 2007·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Srinivasu KallakuriJohn M Cavanaugh
Feb 10, 2012·Journal of Neuropathology and Experimental Neurology·Thomas M ReevesLinda L Phillips
Dec 29, 2009·European Journal of Ophthalmology·Chetan R Soni, Lenworth N Johnson
Dec 21, 2012·Journal of Neurotrauma·Douglas H SmithJohn T Povlishock
Feb 22, 2017·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Fraser C HendersonNicol C Voermans
Feb 6, 2016·Molecular Neurobiology·Elke YdensVeerle Somers
May 7, 2005·Acta Neuropathologica·Alejandra C Rodriguez-PaezHelen M Bramlett
Dec 19, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Min D Tang-SchomerDouglas H Smith
Dec 31, 2010·Journal of Neurotrauma·Ahmed Mohammed SulaimanWilliam L Maxwell
May 29, 2013·CNS Neuroscience & Therapeutics·Shoji YokoboriRoss Bullock
Jul 1, 1997·Journal of Neurotrauma·W L MaxwellD L Graham
Jan 18, 2011·Journal of Neurotrauma·Jerome A Staal, James C Vickers
Jan 4, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·William L Maxwell

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