Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

Frontiers in Neuroscience
Andrew KneynsbergNicholas M Kanaan

Abstract

Tauopathies are a diverse group of diseases featuring progressive dying-back neurodegeneration of specific neuronal populations in association with accumulation of abnormal forms of the microtubule-associated protein tau. It is well-established that the clinical symptoms characteristic of tauopathies correlate with deficits in synaptic function and neuritic connectivity early in the course of disease, but mechanisms underlying these critical pathogenic events are not fully understood. Biochemical in vitro evidence fueled the widespread notion that microtubule stabilization represents tau's primary biological role and that the marked atrophy of neurites observed in tauopathies results from loss of microtubule stability. However, this notion contrasts with the mild phenotype associated with tau deletion. Instead, an analysis of cellular hallmarks common to different tauopathies, including aberrant patterns of protein phosphorylation and early degeneration of axons, suggests that alterations in kinase-based signaling pathways and deficits in axonal transport (AT) associated with such alterations contribute to the loss of neuronal connectivity triggered by pathogenic forms of tau. Here, we review a body of literature providing evid...Continue Reading

References

Oct 25, 1977·Journal of Molecular Biology·D W ClevelandM W Kirschner
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M D WeingartenM W Kirschner
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P A LoomisL I Binder
Jan 1, 1987·Cell Motility and the Cytoskeleton·S C Papasozomenos, L I Binder
Jan 1, 1968·Archives of Neurology·J J RebeizE P Richardson
May 1, 1996·Journal of Neuropathology and Experimental Neurology·S S Chin, J E Goldman
Dec 20, 1996·The Journal of Biological Chemistry·G CarmelJ Kuret
Apr 18, 1998·Brain Pathology·D W Dickson
Aug 15, 1998·The Journal of Biological Chemistry·H LiaoG G Gundersen
Apr 1, 1999·Acta Neurologica Scandinavica·T DoiM Takamori
Jul 13, 1999·Cell Motility and the Cytoskeleton·C W LiuD G Jay
Dec 22, 1999·Journal of Neuropathology and Experimental Neurology·J R MurrellM Goedert

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Citations

Jun 15, 2018·Expert Review of Neurotherapeutics·Farwa Ali, Keith Josephs
Aug 21, 2019·Central Nervous System Agents in Medicinal Chemistry·Anurag K SinghGiriraj T Kulkarni
Jun 17, 2020·Expert Opinion on Drug Discovery·Dasol KimHo Jeong Kwon
Apr 8, 2020·Frontiers in Cellular Neuroscience·Danira Toral-RiosVictoria Campos-Peña
Oct 3, 2020·Scientific Reports·Deborah A CoreyThomas J Kelley
Aug 29, 2018·Proceedings of the National Academy of Sciences of the United States of America·Daniel W SummersAaron DiAntonio
Mar 7, 2019·Frontiers in Neuroinformatics·Artemis Zavaliangos-PetropuluPaul M Thompson
Oct 22, 2019·Frontiers in Cellular Neuroscience·Yanina Ivashko-Pachima, Illana Gozes
May 28, 2020·Journal of Personalized Medicine·Md Shahjalal Hossain Khan, Vijay Hegde
Jan 31, 2020·Nature Communications·Luca FerrariStefan G D Rüdiger
Jul 28, 2020·International Journal of Molecular Sciences·Elena VacchiGiorgia Melli
Dec 25, 2019·Progress in Neurobiology·Daniela RossiEduardo Soriano
Dec 22, 2020·Frontiers in Molecular Neuroscience·Yoshiyuki Soeda, Akihiko Takashima
Apr 6, 2021·Frontiers in Molecular Neuroscience·Rebecca L MuellerNicholas M Kanaan
May 15, 2021·Frontiers in Molecular Neuroscience·Nicholas M Kanaan, Tessa Grabinski
Jun 21, 2021·Acta Neuropathologica Communications·Harrison Tudor EvansJürgen Götz
Jun 27, 2021·Biochemical and Biophysical Research Communications·Dasol KimHo Jeong Kwon
Aug 28, 2021·Brain Sciences·Neha MohanPeter W Baas
Sep 16, 2021·Journal of Food Biochemistry·Moazzama AkbarMuhammad Ajmal Shah
Nov 3, 2021·Nature Reviews. Neuroscience·Pranesh PadmanabhanJürgen Götz
Aug 17, 2021·Brain : a Journal of Neurology·Negin HollandJames B Rowe

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Methods Mentioned

BETA
imaging techniques
transgenic
immunodepletion
phosphotransferases
phosphotransferase

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