Axonal dependency of the postnatal upregulation in neurofilament expression

Journal of Neuroscience Research
M L SchwartzW W Schlaepfer

Abstract

A coordinated up-regulation in the expression of all three neurofilament (NF) proteins occurs during postnatal development in the rat (Schlaepfer and Bruce, J Neurosci Res [in press], 1990a). In the present study, sciatic nerves were transected in neonatal rats in order to determine the effects of axotomy on the postnatal upregulation of NF expression in neurons of rat dorsal root ganglia (DRG). Left sciatic nerves were transected at postnatal day 3 (P3), 6 (P6), 8 (P8), or 10 (P10). mRNA and protein levels of the light (NF-L), mid-sized (NF-M), and heavy (NF-H) NF proteins were compared in L4 and L5 DRGs from the transected (left) vs. control (right) sides of the same animals at varying intervals after transection. When nerves were transected at P10, mRNA levels of all three NF proteins declined markedly in the parent DRG neurons, thereby completely interrupting the postnatal upregulation of NF expression. P10 transections also led to widespread chromatolytic changes in axotomized neurons, indistinguishable from those that occur in adult DRG following sciatic nerve transection (Goldstein et al., J Neurosci 7:1586-1594, 1987). Nerve transections at earlier (e.g., P3) neonatal timepoints also led to a decrease of NF expression, ...Continue Reading

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Citations

Jan 1, 1994·Acta neurochirurgica·K TanakaT Taniguchi
Dec 1, 1994·Brain Research. Molecular Brain Research·M L SchwartzW W Schlaepfer
Apr 18, 2002·Journal of the Neurological Sciences·Catherine FressinaudFrederic Dubas
Apr 13, 2007·Experimental Cell Research·Amar ThyagarajanBen G Szaro
Mar 21, 2006·Gene·Sang Eun LeeHye-Young Yun
Feb 26, 2016·Journal of Cell Science·Chen Wang, Ben G Szaro
Nov 6, 2018·Journal of Neuroscience Research·Meng-Lin LiaoChung-Liang Chien
Jun 20, 1998·The Journal of Biological Chemistry·R Cañete-SolerW W Schlaepfer
Nov 3, 1995·The Journal of Biological Chemistry·M L SchwartzW W Schlaepfer
May 2, 2003·The Journal of Comparative Neurology·Christine GervasiBen G Szaro

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