Axonal excitability in viral polyneuropathy and nucleoside neuropathy in HIV patients

Journal of Neurology, Neurosurgery, and Psychiatry
Karl NgDavid Burke

Abstract

HIV infection is associated with several forms of peripheral neuropathy, the most common being a distal symmetrical polyneuropathy due to HIV infection ('DSP'). Direct viral effects are an important cause (hereafter termed viral neuropathy (VN)), but sometimes, it is due to nucleoside antiretroviral drug therapy (nucleoside neuropathy (NN)). Mechanisms of disease are incompletely understood, with some evidence implicating HIV envelope glycoprotein gp120 mediated neuronal apoptosis for the former and mitochondrial toxicity ± DNA polymerase γ involvement in the latter. The authors studied 16 HIV positive patients, 14 of whom had neuropathy (10 VN; 4 NN), clinically, with conventional nerve-conduction studies (NCS), and with measurements of the excitability of motor and sensory axons in the median nerve. Clinically neuropathic patients were all symptomatic, and 12 had abnormalities in NCS. There were no changes in the excitability of sensory or motor axons in VN, but there were in the NN group. These were consistent with depolarisation of the internodal membrane ('fanned in' threshold electrotonus, increased resting current--voltage slope, reduced superexcitability) but with sparing of nodal properties (absolute threshold, strengt...Continue Reading

Citations

Feb 19, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Stacey K Jankelowitz, David Burke
Oct 22, 2013·Current Infectious Disease Reports·Kate M Crossley, Bruce J Brew
Jun 19, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Luc BertrandMichal Toborek
Nov 24, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Thomas JulianPanagiotis Zis

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