Axonal excitability measured by tracking twitch contraction force

Muscle & Nerve
Louise TrevillionD Burke

Abstract

The present study addressed whether the excitability of motor axons could be documented by tracking a target submaximal contraction force rather than a target submaximal compound muscle action potential (CMAP). In 10 subjects, multiple excitability measures were recorded using the Trond protocol, tracking twitch contraction force and the CMAP in response to stimulation of the median nerve at the wrist and twitch force to stimulation at the motor point. With stimulation at the wrist, the findings were virtually identical with force tracking and CMAP tracking for indices dependent on unconditioned thresholds (stimulus-response curves; strength-duration properties) and when the conditioning stimulus was subthreshold (threshold electrotonus; current-threshold relationship). However, when the conditioning stimulus was supramaximal, as in recovery cycle studies, thresholds for the target force were lower in all subjects than for the target CMAP. There was variability between different subjects in the extent of this offset. However, force tracking can still be used to follow changes in refractoriness and supernormality when membrane potential changes during an experiment. The excitability indices differed with motor point stimulation,...Continue Reading

References

Sep 1, 1991·Journal of Neurology, Neurosurgery, and Psychiatry·W F Brown, R Snow
Nov 10, 2001·Brain : a Journal of Neurology·C Cappelen-SmithD Burke
Dec 18, 2001·Muscle & Nerve·R J WaltersH Bostock
Feb 3, 2004·Muscle & Nerve·Satoshi KuwabaraTakamichi Hattori

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Citations

Jun 13, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Miho NakataHugh Bostock

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