Axonal Guidance Signaling Pathway Is Suppressed in Human Nasal Polyps

American Journal of Rhinology & Allergy
Dawei WuBenjamin S Bleier

Abstract

Background Dysfunctional innervation might contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP), but the state of the axonal outgrowth signaling in CRSwNP is unknown. The purpose of this study was to explore the axonal outgrowth pathway-related protein expression in CRSwNP. Methods Institutional review board approved study in which tissue proteomes were compared between control and CRSwNP patients (n = 10/group) using an aptamer-based proteomic array and confirmed by whole transcriptomic analysis. Results Compared with controls, proteins associated with axonal guidance signaling pathway such as beta-nerve growth factor, semaphorin 3A, Ras-related C3 botulinum toxin substrate 1, Bcl-2, protein kinase C delta type, and Fyn were significantly decreased in patients with CRSwNP (fold change [FC] = -1.17, P = .002; FC = -1.09, P < .001; FC = -1.33, P < .001; FC = -1.31, P < .001; FC = -1.31, P = .004; and FC = -1.20, P = 0.012, respectively). In contrast, reticulon-4 receptor, an inhibitory factor, was significantly increased in patients with CRSwNP (FC = 1.25, P < .001). Furthermore, neuronal growth-associated proteins such as ciliary neurotrophic factor receptor subunit alpha, neuronal growth regulato...Continue Reading

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Citations

Apr 3, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ashton E LehmannRalph Metson
Jul 31, 2018·American Journal of Rhinology & Allergy·Harshita Pant
Oct 12, 2020·International Forum of Allergy & Rhinology·Jie DengNoam A Cohen
Nov 19, 2020·Molecular Aspects of Medicine·Lei WanFu-Tong Liu

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Methods Mentioned

BETA
Protein Assay
Assay

Software Mentioned

SOMAscan
Ingenuity Pathway Analysis ( IPA )
GeneMANIA
HISAT27
SomaLogic
Morpheus
StringTie
IPA
[UNK]
Ballgown

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