PMID: 11920722Mar 29, 2002Paper

Axonal projections of pulmonary slowly adapting receptor relay neurons in the rat

The Journal of Comparative Neurology
Kazuhisa EzureKazuyoshi Otake

Abstract

We elucidated efferent projections of second-order relay neurons (P-cells) activated by afferents originating from slowly adapting pulmonary receptors (SARs) to determine the central pathway of the SAR-evoked reflexes. Special attention was paid to visualizing the P-cell projections within the nucleus tractus solitarii (NTS), which may correspond to the inhibitory pathway from P-cells to second-order relay neurons (RAR-cells) of rapidly adapting pulmonary receptors. P-cells were recorded from the NTS in Nembutal-anesthetized, paralyzed, and artificially ventilated rats. First, we used electrophysiological methods of antidromic mapping and showed that the majority of the P-cells examined projected their axons to the caudal NTS and to the dorsolateral pons corresponding to the parabrachial complex. Second, a mixture of HRP and Neurobiotin was injected intracellularly or juxtramembranously into P-cells. (1) Stained P-cells (n = 7) were located laterally to the solitary tract and had dendrites extending characteristically along the lateral border of the solitary tract. (2) All P-cells had stem axons projecting to the ipsilateral medulla. Of these, the axons from five P-cells projected to the nucleus ambiguus and its vicinity with d...Continue Reading

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Citations

May 6, 2009·Clinical and Experimental Pharmacology & Physiology·Daniel B ZoccalBenedito H Machado
Jul 18, 2008·Journal of Neurophysiology·Lauren S SegersBruce G Lindsey
Sep 15, 2014·Respiratory Physiology & Neurobiology·Eduardo V Lemes, Daniel B Zoccal
Feb 3, 2016·Brain Research·John Ciriello, Monica M Caverson
Jan 27, 2007·The Journal of Physiology·Thiago S MoreiraPatrice G Guyenet
Feb 10, 2004·The Journal of Physiology·Nicholas M MellenJack L Feldman
Jul 11, 2006·The Journal of Physiology·Angelina Y Fong, Jeffrey T Potts
Jul 12, 2011·Respiratory Physiology & Neurobiology·Ralph F Fregosi
Sep 15, 2010·Autonomic Neuroscience : Basic & Clinical·Thiago S MoreiraEduardo Colombari
Aug 19, 2008·Respiratory Physiology & Neurobiology·George F Alheid, Donald R McCrimmon
Jul 16, 2008·Respiratory Physiology & Neurobiology·Mathias DutschmannMiriam Kron
Aug 20, 2010·The European Journal of Neuroscience·Amandine DufourAgnès Baude
Nov 3, 2004·Respiratory Physiology & Neurobiology·Kazuhisa Ezure
May 26, 2009·Autonomic Neuroscience : Basic & Clinical·Weirong ZhangPaul W Davenport
Jul 11, 2014·Frontiers in Physiology·Daniel B ZoccalEduardo Colombari
Dec 2, 2014·Medical Hypotheses·Ravinder JerathKyler Harden
Dec 23, 2003·The Journal of Comparative Neurology·Fabrice RodaChristian Gestreau
Apr 29, 2006·Journal of Applied Physiology·Leszek KubinDonald R McCrimmon
Apr 27, 2007·Journal of Neurophysiology·Ana C TakakuraPatrice G Guyenet
Dec 7, 2007·Journal of Neurophysiology·Angelina Y Fong, Jeffrey T Potts
Feb 15, 2008·Journal of Neurophysiology·Timothy W BaileyMichael C Andresen
Jun 10, 2016·Physiological Reviews·Stuart B Mazzone, Bradley J Undem
Mar 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael B Harris, Walter M St -John
Jun 27, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Josiane N SilvaAna C Takakura
Mar 31, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vitaliy Marchenko, Robert F Rogers
Jul 18, 2018·Frontiers in Physiology·Kofi-Kermit HortonChristian Gestreau
Apr 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael B Harris, Walter M St-John
Sep 18, 2020·Respiratory Physiology & Neurobiology·Ivan PoliacekJana Plevkova

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