PMID: 9545086Apr 17, 1998Paper

Axonal regrowth through a collagen guidance channel bridging spinal cord to the avulsed C6 roots: functional recovery in primates with brachial plexus injury

Journal of Neuroscience Research
S LiuMarc Tadié

Abstract

Intraspinal implantation of a collagen guidance channel (CGC) to promote axon regeneration was investigated in marmosets with brachial plexus injury. After avulsion of the right C5, C6 and C7 spinal roots, a CGC containing (group B) or not (group A) a nerve segment, or a nerve graft (group C), was ventro-laterally implanted into the cord to bridge the ventral horn and the avulsed C6 roots. No spinal cord dysfunction was observed following surgery. Two months later, the postoperative flaccid paralysis of the lesioned arm improved. In five months, a normal electromyogram of the affected biceps muscle was recorded in all repaired animals. Motor evoked potentials were obtained with a mean amplitude of 13.37 +/- 13.66 microV in group A, 13.21 +/- 5.16 microV in group B and 37.14 +/- 35.16 microV in group C. The force of biceps muscle contraction was 27.33 +/- 20.03 g (group A), 24.33 +/- 17.03 g (group B) and 37.38 +/- 21.70 g (group C). Retrograde tracing by horseradish peroxidase showed labelled motoneurons ipsilaterally located in the C5 and C6 ventral horn, nearby the implantation site. The mean labelled neurons was 32.33 +/- 21.13, 219.33 +/- 176.29 and 64.33 +/- 23.54 in group A, B and C respectively. Histological analysis pre...Continue Reading

Citations

Jan 1, 2008·International Journal of Nanomedicine·Justin T Seil, Thomas J Webster
Aug 25, 2009·Journal of Neurotrauma·Karin S StraleySarah C Heilshorn
Mar 10, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Silvia SniderPietro Mortini
Sep 3, 2004·The European Journal of Neuroscience·Xiao-Qing TangGeorge M Smith
Feb 7, 2001·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·P HaninecL Stejskal
Apr 25, 2006·Cellular and Molecular Neurobiology·Eva SykováAles Hejcl
Aug 27, 2005·Journal of Biomedical Materials Research. Part a·Ning ZhangXuejun Wen
Jun 18, 2014·Regenerative Medicine·Fanwei MengStephen F Badylak
Jul 4, 2006·Journal of Biomedical Materials Research. Part a·Hang LinJianwu Dai

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