Axonal reinjury reveals the survival and re-expression of regeneration-associated genes in chronically axotomized adult mouse motoneurons

Experimental Neurology
Lowell T McPhailWolfram Tetzlaff

Abstract

Recently, we reported that chronically axotomized rubrospinal neurons survive for up to 1 year in an atrophied state. This finding contrasted previous work suggesting the death of up to 50% of the neurons over time. In the adult mouse, the majority of facial motoneurons appear to be lost as a result of chronic nerve resection. Here, we sought to determine if chronically resected adult mouse facial motoneurons, like rubrospinal neurons, survive in an atrophied state. To test this hypothesis, we asked whether a second nerve injury, 10 weeks after an initial nerve resection, could stimulate a regenerative cell body response. After chronic resection (10 weeks), mouse facial motoneurons underwent atrophy resulting in a loss of countable neuronal cell bodies. In addition, the motoneurons failed to maintain their initial increase in expression of GAP-43 and alpha-tubulin mRNA. Reinjury of 10-week chronically resected facial motoneurons by the removal of the neuroma reversed the atrophy of the cell bodies and increased the percentage of identifiable cell bodies from 36% of contralateral to 79% in C57BL/6-C3H mice and from 28% of contralateral to 40% in Balb/c mice. Moreover, the reinjured motoneurons displayed an increase in GAP-43 and...Continue Reading

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Citations

Jun 7, 2005·Experimental Neurology·Lowell T McPhailWolfram Tetzlaff
Jul 1, 2008·Molecular and Cellular Neurosciences·Ruben EggersJoost Verhaagen
Apr 19, 2007·The European Journal of Neuroscience·Daniel P Ankeny, Phillip G Popovich
Sep 8, 2007·The European Journal of Neuroscience·Ok-hee ParkWoong Sun
Apr 5, 2014·The Journal of Comparative Neurology·Zachary R GallaherKrzysztof Czaja
Mar 27, 2012·Archives of Physical Medicine and Rehabilitation·Martina R SpiessCarolynn Patten
Sep 30, 2015·The European Journal of Neuroscience·Ruben EggersJoost Verhaagen
Feb 28, 2009·The Annals of Otology, Rhinology, and Laryngology·Jonas Hydman, Per Mattsson
Sep 15, 2011·The Journal of Hand Surgery, European Volume·S A HoyngM J A Malessy
Nov 25, 2017·Neural Regeneration Research·Sheng-Min LaiJing Liu
Nov 21, 2007·Nature Neuroscience·Bahareh AjamiFabio M V Rossi
May 31, 2015·Journal of Molecular Neuroscience : MN·Min TanLi Hua Zhou
Jan 8, 2021·Frontiers in Neuroscience·Joseph R LoverdeBryan J Pfister

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