Abstract
Recently, we reported that chronically axotomized rubrospinal neurons survive for up to 1 year in an atrophied state. This finding contrasted previous work suggesting the death of up to 50% of the neurons over time. In the adult mouse, the majority of facial motoneurons appear to be lost as a result of chronic nerve resection. Here, we sought to determine if chronically resected adult mouse facial motoneurons, like rubrospinal neurons, survive in an atrophied state. To test this hypothesis, we asked whether a second nerve injury, 10 weeks after an initial nerve resection, could stimulate a regenerative cell body response. After chronic resection (10 weeks), mouse facial motoneurons underwent atrophy resulting in a loss of countable neuronal cell bodies. In addition, the motoneurons failed to maintain their initial increase in expression of GAP-43 and alpha-tubulin mRNA. Reinjury of 10-week chronically resected facial motoneurons by the removal of the neuroma reversed the atrophy of the cell bodies and increased the percentage of identifiable cell bodies from 36% of contralateral to 79% in C57BL/6-C3H mice and from 28% of contralateral to 40% in Balb/c mice. Moreover, the reinjured motoneurons displayed an increase in GAP-43 and...Continue Reading
References
Mar 1, 1992·Trends in Neurosciences·M B Lowrie, G Vrbová
Oct 1, 1992·The Journal of Cell Biology·M MeyerH Thoenen
Oct 1, 1991·The Journal of Cell Biology·K A StöckliM Sendtner
Jan 1, 1990·Neuroscience·C J WoolfL I Benowitz
Dec 25, 1989·Brain Research·T HaggS Varon
Apr 1, 1988·Journal of Neurocytology·M B Graeber, G W Kreutzberg
Jun 1, 1987·The Journal of Cell Biology·R HeumannH Thoenen
Jul 1, 1986·Molecular and Cellular Biology·A VillasanteN J Cowan
Sep 1, 1985·The Journal of Cell Biology·S A LewisN J Cowan
Feb 1, 1995·Glia·D N AngelovW F Neiss
Aug 1, 1993·Developmental Biology·W WuF D Miller
Jan 1, 1994·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·O Guntinas-LichiusE Stennert
Nov 11, 1994·Science·C E HendersonA Rosenthal
Oct 1, 1993·The Journal of Cell Biology·H FunakoshiH Persson
Mar 1, 1996·Experimental Neurology·J P RossiterM A Bisby
Apr 1, 1996·Neuroscience·F de Bilbao, M Dubois-Dauphin
Feb 1, 1996·Glia·D N AngelovE Stennert
Jan 1, 1996·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·R Laskawi, J R Wolff
Jan 1, 1997·Experimental Neurology·F MoriA Tessler
Jul 1, 1997·The European Journal of Neuroscience·P NaveilhanP Ernfors
May 1, 1999·Experimental Neurology·O StewardT McIntosh
Dec 1, 1999·Neuroscience·J D Houle, J H Ye
Oct 6, 2000·Journal of Neuroscience Research·C J SerpeK J Jones
Oct 13, 2000·The European Journal of Neuroscience·J L VanderluitW Tetzlaff
Jan 25, 2002·The Journal of Cell Biology·Ulrich SchweizerMichael Sendtner
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brian K KwonWolfram Tetzlaff
May 31, 2002·Journal of Neurocytology·L B MoranM B Graeber
Sep 28, 2002·Neuroreport·Olle LidmanFredrik Piehl
Dec 31, 2003·Experimental Neurology·Lowell T McPhailWolfram Tetzlaff
Citations
Oct 24, 2007·Experimental Brain Research·N SinisD N Angelov
Aug 23, 2005·Brain Research. Brain Research Reviews·I DusartC Sotelo
Jun 7, 2005·Experimental Neurology·Lowell T McPhailWolfram Tetzlaff
Jul 31, 2008·Parasitology·A B M da SilveiraD d'Avila Reis
Jan 25, 2005·Journal of Neurotrauma·Myriam DjebailiDonald G Stein
Aug 28, 2012·Neuroscience Letters·Zhi HuangJohn M Petitto
Mar 26, 2011·Neuroscience·J YamadaS Jinno
Dec 21, 2010·Archives of Medical Research·Long-Ju ChenFeng Li
Jul 1, 2008·Molecular and Cellular Neurosciences·Ruben EggersJoost Verhaagen
Jun 10, 2008·Journal of Neuroimmunology·Grace K HaJohn M Petitto
Apr 19, 2007·The European Journal of Neuroscience·Daniel P Ankeny, Phillip G Popovich
Sep 8, 2007·The European Journal of Neuroscience·Ok-hee ParkWoong Sun
Apr 5, 2014·The Journal of Comparative Neurology·Zachary R GallaherKrzysztof Czaja
Dec 3, 2014·Experimental Neurology·T GordonW Tetzlaff
Nov 14, 2014·PloS One·Daria GusevaMelitta Schachner
Dec 27, 2005·Journal of Neuroimmunology·Grace K HaJohn M Petitto
Mar 27, 2012·Archives of Physical Medicine and Rehabilitation·Martina R SpiessCarolynn Patten
Sep 30, 2015·The European Journal of Neuroscience·Ruben EggersJoost Verhaagen
Feb 28, 2009·The Annals of Otology, Rhinology, and Laryngology·Jonas Hydman, Per Mattsson
Sep 15, 2011·The Journal of Hand Surgery, European Volume·S A HoyngM J A Malessy
Jul 10, 2008·Neurorehabilitation and Neural Repair·Emilia EvgenievaDoychin N Angelov
Nov 25, 2017·Neural Regeneration Research·Sheng-Min LaiJing Liu
Nov 21, 2007·Nature Neuroscience·Bahareh AjamiFabio M V Rossi
May 31, 2015·Journal of Molecular Neuroscience : MN·Min TanLi Hua Zhou
May 20, 2005·Brain : a Journal of Neurology·P G BannermanD Pleasure
Aug 18, 2020·Neural Plasticity·Yusu NiHuawei Li
Jan 8, 2021·Frontiers in Neuroscience·Joseph R LoverdeBryan J Pfister
Jun 30, 2021·Ultrastructural Pathology·Leman SencarSait Polat
Mar 8, 2011·Experimental Neurology·Daria GusevaMelitta Schachner