Abstract
The purpose of this study was to investigate the prevalence of peripheral neuropathy in patients with beta-thalassaemia. Thirty six patients with a mean age of 29.2+/-8.2 years and 17 healthy controls with a mean age of 27.6+/-9.1 were included in this study. Measurements included the neuropathy symptoms score (NSS), the neuropathy disability score (NDS) as well as nerve conduction studies of two motor (ulnar and peroneal) and two sensory (ulnar and sural) nerves of the right limbs. A mainly sensory axonal polyneuropathy was present in 19 out of 36 patients (52.7%). Eight out of these 19 patients also had abnormal NDS values. The neuropathy correlated significantly with the age of the patients and the hematocrit. However, it did not correlate with the presence of antibodies against HCV, the ferritin levels, or with a history of transfusions, desferrioxamine treatment, or splenectomy. This study showed a high prevalence of a predominantly sensory neuropathy in patients with beta-thalassaemia. The electrophysiological data suggest that the underlying pathology is an axonopathy. Chronic hypoxia of the nerves resulting from severe anaemia may contribute to the pathogenesis of this neuropathy.
Citations
Dec 16, 2011·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Elefterios StamboulisGeorgios Tsivgoulis
Mar 1, 2005·Journal of Clinical Neuromuscular Disease
Dec 2, 2008·Acta Physiologica·I VasileiadisS Nanas
Jan 15, 2014·Antioxidants & Redox Signaling·Sonia Levi, Carla Taveggia
Feb 8, 2011·International Journal of Cardiology·Josef FinstererElisabeth Schreiber
Mar 4, 2008·Scandinavian Journal of Medicine & Science in Sports·S NanasA Aessopos
Apr 1, 2006·Brain & Development·Dimitrios I ZafeiriouMiranta Athanasiou-Metaxa
Apr 24, 2015·Annals of Hematology·P NemtsasA Orologas
Oct 15, 2010·Journal of Clinical Neurology·Elefterios StamboulisGeorgios Tsivgoulis
May 25, 2016·Sleep & Breathing = Schlaf & Atmung·Özgür Bilgin TopçuoğluKayıhan Uluç
Sep 12, 2018·Hemoglobin·Turan BayhanFatma Gümrük
Feb 11, 2018·Annals of Hematology·P NemtsasA Orologas
Jan 18, 2019·Journal of Toxicology and Environmental Health. Part a·Robyn M Amos-KroohsPatricia Setton-Avruj
Oct 12, 2019·International Ophthalmology·Samira HeydarianMehdi Khabazkhoob
Oct 20, 2018·Indian Journal of Pediatrics·Jaya Shankar KaushikAlka Yadav
Aug 8, 2019·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Mona H El-TaguiAmina Abdel-Salam
Feb 6, 2021·Neuroscience and Biobehavioral Reviews·Deborah ChiabrandoEmanuela Tolosano