Axonal transection in the lesions of multiple sclerosis

The New England Journal of Medicine
B D TrappL Bö

Abstract

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system and is the most common cause of neurologic disability in young adults. Despite antiinflammatory or immunosuppressive therapy, most patients have progressive neurologic deterioration that may reflect axonal loss. We conducted pathological studies of brain tissues to define the changes in axons in patients with multiple sclerosis. Brain tissue was obtained at autopsy from 11 patients with multiple sclerosis and 4 subjects without brain disease. Fourteen active multiple-sclerosis lesions, 33 chronic active lesions, and samples of normal-appearing white matter were examined for demyelination, inflammation, and axonal pathologic changes by immunohistochemistry and confocal microscopy. Axonal transection, identified by the presence of terminal axonal ovoids, was detected in all 47 lesions and quantified in 18 lesions. Transected axons were a consistent feature of the lesions of multiple sclerosis, and their frequency was related to the degree of inflammation within the lesion. The number of transected axons per cubic millimeter of tissue averaged 11,236 in active lesions, 3138 at the hypocellular edges of chronic active lesions, 875 in the hypoc...Continue Reading

References

Mar 1, 1991·The Journal of Clinical Investigation·K SelmajC F Brosnan
May 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·N M MilliganD A Compston
Oct 1, 1973·Journal of Neurochemistry·W T Norton, S E Poduslo
Apr 1, 1984·The Journal of Cell Biology·N HirokawaM B Willard
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L A Sternberger, N H Sternberger
Jan 1, 1984·Annals of the New York Academy of Sciences·J W PrineasL R Sharer
Jul 1, 1995·Brain Research. Molecular Brain Research·V Mehta, M A Namboodiri
Mar 1, 1995·The European Journal of Neuroscience·M FruttigerR Martini
Jan 1, 1994·Acta Neuropathologica·F E SherriffS Wilson
Jul 1, 1994·Journal of Neuropathology and Experimental Neurology·W I McDonald
Feb 1, 1994·Brain : a Journal of Neurology·C A DavieW I McDonald
Nov 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·N De StefanoD L Arnold
Jan 1, 1995·Duodecim; lääketieteellinen aikakauskirja·M PaneliusJ Ruutiainen
Aug 1, 1996·Nature Genetics·G C EbersN Risch
May 1, 1996·Neurologic Clinics·B G Weinshenker
Dec 1, 1996·Brain : a Journal of Neurology·N A LosseffA J Thompson
Mar 1, 1997·Brain : a Journal of Neurology·B FergusonV H Perry

❮ Previous
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Citations

Jan 14, 2009·Archives of Neurology·Natalia M MollRichard M Ransohoff
Sep 14, 2011·Archives of Neurology·Robert T NaismithAnne H Cross
Apr 15, 2000·Journal of Clinical Apheresis·R Weinstein
Feb 13, 2001·Journal of Neuroscience Research·A I BoullerneJ A Benjamins
Jan 23, 1999·Annals of Neurology·S Scherer
Feb 9, 2002·Annals of Neurology·Natalija PopovicIan D Duncan
Jan 2, 2003·Annals of Neurology·Richard A Lewis, Robert P Lisak
Nov 15, 2001·Annals of Neurology·J W PrineasB P Morgan
May 31, 2002·Rehabilitation Nursing : the Official Journal of the Association of Rehabilitation Nurses·N HollandL Smith-Williamson
Jul 12, 2002·Journal of Neuroscience Research·Yangzhou Du, Cheryl F Dreyfus
Jul 31, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G Helms
Mar 27, 2001·Muscle & Nerve·R Martini
Apr 21, 2007·Current Treatment Options in Neurology·Adrienne Boissy, Robert J Fox
Jul 2, 2003·Neurotoxicity Research·Carl Bjartmar, Bruce D Trapp
Nov 15, 2002·International Journal of Hematology·Richard K BurtAlberto M Marmont
Jan 16, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·C Infante-DuarteF Zipp
May 7, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tobias DerfussEdgar Meinl
Mar 15, 2005·Der Nervenarzt·C EngelU K Zettl
Jul 16, 2011·Der Nervenarzt·F Zipp, R Gold
Oct 2, 2013·Der Nervenarzt·M PlattenR Diem
May 9, 2007·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·W A Lagrèze
Mar 21, 2006·Acta Neuropathologica·Maria Diaz-SanchezMargaret M Esiri

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