PMID: 6169394Sep 28, 1981Paper

Axonal transport maintains taste responses

Brain Research
B OakleyL B Jones

Abstract

Transection of the gerbil's IXth nerve causes gustatory action potentials to decline in 1-6 h; the rate of decline is a linear function of the length of the nerve stump remaining attached to the tongue. To test the implication that taste discharge mechanisms depend upon axonal transport in the IXth nerve, we injected 40 nl of [3H]leucine into the petrosal ganglion of one IXth nerve of the gerbil, Meriones unguiculatus. Subsequent liquid scintillation counting of the petrosal ganglion, IXth nerve segments, and representative areas of the tongue indicated that labeled materials were transported down the IXth nerve primarily to the vallate and ipsilateral foliate taste papillae of the tongue. A significant impairment of axonal transport and a substantial decline in summated IXth nerve taste responses occurred within 2-3 h after colchicine was applied to the IXth nerve trunk between the tongue and the petrosal ganglion. Similarly, cooling the IXth nerve with a 3-10 degrees C thermocouple junction or metal probe impaired axonal transport and caused a taste response decline. Since impulse mechanisms of the nerve trunk continued to function distal to these sites of treatment, we concluded that the maintenance of taste discharges at th...Continue Reading

References

Jul 1, 1976·Journal of Neurobiology·B CosensS Brimijoin
Aug 25, 1978·Cell and Tissue Research·M L Rodrigo AnguloE L Rodríguez-Echandía
Jan 1, 1977·Acta Anatomica·F A StateA A Bondok
Jul 19, 1974·Brain Research·B Oakley
Nov 1, 1965·The Journal of Cell Biology·L M Beidler, R L Smallman
Jul 21, 1980·Brain Research·B OakleyM A Hosley
Jul 1, 1980·Cell and Tissue Kinetics·A I Farbman

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Citations

Nov 1, 1984·Brain Research·B OakleyS E Hughes
Jun 16, 1983·Neuroscience Letters·S E HughesB Oakley
Dec 24, 1998·Peptides·G Scalera, G Tarozzi
Dec 1, 1982·The Journal of Cell Biology·P Cancalon
Jun 1, 1988·The Journal of General Physiology·M E FrankD V Smith
Feb 14, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·John GardinerRobyn Overall
May 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Giuseppe Scalera

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