PMID: 6171326Dec 14, 1981Paper

Axonal transport of enzymes and labeled proteins in experimental axonopathy induced by p-bromophenylacetylurea

Brain Research
J Jakobsen, S Brimijoin

Abstract

Axonal transport was studied by several techniques in the sciatic nerves of adult male Sprague-Dawley rats with neuropathy induced by treatment with p-bromophenylacetylurea (BPAU) in dimethylsulfoxide solution. Control rats were treated with solvent alone. BPAU, 200 mg/kg, induced severe muscle weakness in the hindlimbs, beginning after a latent period of 1 week and progressing to near total paralysis by 2 weeks. Axonal transport of the endogenous transmitter enzymes, acetylcholinesterase, dopamine-beta-hydroxylase and choline acetyltransferase, was normal at both 2 and 15 days after administration of BPAU, as judged by the accumulation of enzyme activity above and below a set of double ligatures on the sciatic nerve. The velocity of fast anterograde transport of [35S] methionine labeled protein was also unaffected by BPAU. However, 4 abnormalities of transport were detected in BPAU- treated rats: (1) doubling of the time for initiation of fast anterograde transport after precursor injection in the dorsal root ganglion, (2) 25% fall in the velocity of slow axonal transport of [3H] leucine labeled protein, (3) 30% reduction in the proximal accumulation of fast transported labeled protein in ligated nerve, 8-30 h after injection ...Continue Reading

References

Oct 1, 1975·Canadian Journal of Physiology and Pharmacology·M A Bisby
Sep 14, 1979·Brain Research·P Sidenius, J Jakobsen
Jun 1, 1973·Brain : a Journal of Neurology·W G Bradley, M H Williams
Oct 24, 1969·Science·D E PleasureW K Engel
Oct 1, 1972·Journal of Neurochemistry·V Glover, D P Green
Jan 1, 1969·Brain : a Journal of Neurology·W F Blakemore, J B Cavanagh
Oct 1, 1968·Journal of Neurology, Neurosurgery, and Psychiatry·J B CavanaghA Ridley
Aug 1, 1980·The Journal of Clinical Investigation·J Jakobsen, P Sidenius
Sep 1, 1980·Diabetologia·P Sidenius, J Jakobsen

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Citations

Mar 21, 2007·Expert Reviews in Molecular Medicine·James R Goss
Jul 26, 2008·Nature Nanotechnology·Junping ChenJames F McGinnis
Sep 1, 1986·Journal of Neurology, Neurosurgery, and Psychiatry·J JakobsenH Braendgaard
Oct 1, 1986·Journal of Neurochemistry·D J FinkM Mata
Feb 1, 1983·Muscle & Nerve·J JakobsenP Sidenius

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