PMID: 6161210Jan 1, 1980Paper

Axonal transport of neuropeptides in the cervical vagus nerve of the rat

Journal of Neurochemistry
R F GilbertJ Wass

Abstract

Accumulations of the neuropeptides substance P (SP), somatostatin (ST), and vasoactive intestinal polypeptide (VIP) proximal to a crush in the cervical vagus nerve of the rat have been measured using sensitive radioimmunoassays. Each of the peptides was rapidly transport towards the peripheral terminals of vagal afferent fibres, with average rates of flow ranging from 0.8 to 2.7 mm h-1. In the rabbit vagus nerve, SP was transported with an average rate of 4 mm h-1, which is more than double the rate for this peptide in the rat. Double crush experiments in rabbit vagus nerves indicated that the rapidly transported proportion of the total content of SP in the nerve free was about 34%. From this, the rate of transport of SP in the rapidly transported pool in the rabbit vagus nerve can be calculated to be 12 mm h-1 (280 mm day-1). Since such double crush experiments were not possible in the rat, it is not clear whether the different average rates of transport of SP in the rat and the rabbit reflect real differences in the rate of rapid transport in the two species. In common with rapid axonal transport of other neurotransmitters, the transport of SP and ST in the rat vagus nerve was blocked by colchicine, a drug that disrupts micro...Continue Reading

References

Jun 30, 1975·Annals of the New York Academy of Sciences·A DahlströmN R Saunders
Jan 31, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·R GamseA C Cuello
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Citations

May 1, 1994·Journal of Magnetic Resonance Imaging : JMRI·A G Filler
Jan 1, 1989·Pharmacology & Therapeutics·J Fahrenkrug
Jan 1, 1990·Pharmacology & Therapeutics·M C MioneG Burnstock
Nov 1, 1992·Journal of the Autonomic Nervous System·A Niijima
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Nov 1, 1994·Neurochemistry International·D J ReynoldsR A Leslie
Apr 29, 1983·Neuroscience Letters·G TerenghiJ M Polak
May 1, 1982·Brain Research Bulletin·G Gaudin-ChazalJ J Puizillout
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Mar 29, 2003·Brain Research. Brain Research Reviews·Anthony J M VerberneDaniela M Sartor
Jun 1, 1997·Progress in Neurobiology·H ZhuoC J Helke
Jun 1, 1993·Pharmacology & Toxicology·J Fahrenkrug
Sep 1, 1985·Acta Physiologica Scandinavica·G FriedE Theodorsson-Norheim
Apr 1, 1986·Gut·M R Lucey
Sep 1, 1991·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·J P Niel
Nov 1, 1983·Clinics in Endocrinology and Metabolism·A Gómez-Pan, M D Rodriguez-Arnao
Nov 1, 1983·Clinics in Endocrinology and Metabolism·J A Wass
Dec 1, 1983·Medical Hypotheses·D Trenchard

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