PMID: 6161217Jul 1, 1980Paper

Axonal transport of the Ca2+-dependent protein modulator of 3':5'-cyclic-AMP phosphodiesterase in the rabbit visual system

Journal of Neurochemistry
P F EricksonL N Minier

Abstract

Water-soluble proteins were extracted from individual retinas, optic nerves, combined optic tracts and lateral geniculate bodies, and superior colliculi of rabbits at 1, 3, and 18 days after injection of [3H]leucine into the right eye. The Ca2+-dependent protein modulator of 3':5'-cyclic-AMP phosphodiesterase (calmodulin) was isolated from these samples by a two-step polyacrylamide gel electrophoresis procedure. An analysis of the radioactivity incorporated into the total soluble proteins and the calmodulin revealed that most of the calmodulin was axonally transported at a slow rate (2--4 mm/day) and represented about 0.45% of the total transported soluble protein.

References

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Citations

Jan 1, 1984·Biochimica Et Biophysica Acta·M L VeiglW D Sedwick
Jun 1, 1987·Brain Research Bulletin·M WillardR Cheney
Jan 1, 1995·Brain Research Bulletin·D T RiveraD J Nelson
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J Levine, M Willard
Jan 1, 1988·CRC Critical Reviews in Biochemistry·S R GoodmanI S Zagon
May 1, 1984·British Journal of Pharmacology·V CeñaS M Kirpekar
Jan 1, 1980·Annals of the New York Academy of Sciences·S T BradyR J Lasek

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