PMID: 6166617Jun 1, 1981Paper

Axonal transport of the mitochondria-specific lipid, diphosphatidylglycerol, in the rat visual system

The Journal of Cell Biology
W D BlakerP Morell

Abstract

Rats 24 d old were injected intraocularly with [2-3H]glycerol and [35S]methionine and killed 1 h-60 d later. 35S label in protein and 3H label in total phospholipid and a mitochondria-specific lipid, diphosphatidylglycerol(DPG), were determined in optic pathway structures (retinas, optic nerves, optic tracts, lateral geniculate bodies, and superior colliculi). Incorporation of label into retinal protein and phospholipid was nearly maximal 1 h postinjection, after which the label appeared in successive optic pathway structures. Based on the time difference between the arrival of label in the optic tract and superior colliculus, it was calculated that protein and phospholipid were transported at a rate of about 400 mm/d, and DPG at about half this rate. Transported labeled phospholipid and DPG, which initially comprised 3-5% of the lipid label, continued to accumulate in the visual structures for 6-8 d postinjection. The distribution of transported material among the optic pathway structures as a function of time differed markedly for different labeled macromolecules. Rapidly transported proteins distributed preferentially to the nerve endings (superior colliculus and lateral geniculate). Total phospholipid quickly established a ...Continue Reading

References

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Citations

Apr 1, 1983·Acta Physiologica Scandinavica·J E BergquistP A Hansson
Mar 19, 2003·The Journal of Cell Biology·Anthony Brown
Apr 4, 2009·Experimental Neurology·Qian Cai, Zu-Hang Sheng
Dec 11, 2014·Annals of Clinical and Translational Neurology·Gigi J EbenezerMichael Polydefkis
Jan 4, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kevin C ChanEd X Wu
Nov 1, 1983·Journal of Neurochemistry·M Butler, P Morell

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