Axonal transport: The orderly motion of axonal structures

Methods in Cell Biology
Mark M Black

Abstract

Axonal transport is a constitutive process that supplies the axon and axon terminal with materials required to maintain their structure and function. Most materials are supplied via three rate components termed the fast component, slow component a, and slow component b. Each of these delivers a distinct set of materials with distinct transport kinetics. Understanding the basis for how materials sort among these rate components and the mechanisms that generate their distinctive transport kinetics have been long-standing goals in the field. An early view emphasized the relationships between axonally transported cargoes and cytological structures of the axon. In this article, I discuss key observations that led to this view and contemporary studies that have demonstrated its validity and thereby advanced the current understanding of the dynamics of axonal structure.

Citations

Feb 2, 2017·Small GTPases·Maria Lidia Mignogna, Patrizia D'Adamo
Jun 1, 2017·The Journal of Cell Biology·Archan GangulySubhojit Roy
Oct 17, 2017·Developmental Neurobiology·George M Smith, Gianluca Gallo
Aug 6, 2017·Scientific Reports·Ahmad I M AthamnehKyle E Miller
Nov 2, 2017·Frontiers in Neuroscience·Andrew KneynsbergNicholas M Kanaan
Nov 2, 2019·Traffic·Sunaina SuranaGiampietro Schiavo
Jul 15, 2020·Physical Biology·Saurabh S MogreElena F Koslover
Nov 10, 2020·Advanced Materials·Jia-Qin YangSu-Ting Han
Dec 4, 2020·International Journal of Molecular Sciences·Rossella Di GiaimoMarianna Crispino
Apr 6, 2021·Frontiers in Molecular Neuroscience·Rebecca L MuellerNicholas M Kanaan

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