Axonal wrapping in the Drosophila PNS is controlled by glia-derived neuregulin homolog Vein

Development
Till MatzatChristian Klämbt

Abstract

Efficient neuronal conductance requires that axons are insulated by glial cells. For this, glial membranes need to wrap around axons. Invertebrates show a relatively simple extension of glial membranes around the axons, resembling Remak fibers formed by Schwann cells in the mammalian peripheral nervous system. To unravel the molecular pathways underlying differentiation of glial cells that provide axonal wrapping, we are using the genetically amenable Drosophila model. At the end of larval life, the wrapping glia differentiates into very large cells, spanning more than 1 mm of axonal length. The extension around axonal membranes is not influenced by the caliber of the axon or its modality. Using cell type-specific gene knockdown we show that the extension of glial membranes around the axons is regulated by an autocrine activation of the EGF receptor through the neuregulin homolog Vein. This resembles the molecular mechanism employed during cell-autonomous reactivation of glial differentiation after injury in mammals. We further demonstrate that Vein, produced by the wrapping glia, also regulates the formation of septate junctions in the abutting subperineurial glia. Moreover, the wrapping glia indirectly controls the proliferat...Continue Reading

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Citations

Jul 17, 2015·Wiley Interdisciplinary Reviews. Developmental Biology·Sofia SasseChristian Klämbt
Sep 15, 2015·Brain Research·Stefanie SchirmeierChristian Klämbt
Oct 26, 2010·FEBS Letters·Heon ParkBrian M Iritani
Aug 12, 2016·Scientific Reports·Nils OttoChristian Klämbt
Dec 27, 2016·Journal of Cellular Physiology·Stine Gerdøe-KristensenOle Kjaerulff
Apr 8, 2017·Developmental Neurobiology·Aswati SubramanianJoyce Fernandes
Jul 14, 2018·Development·Selen ZülbaharChristian Klämbt
Jan 24, 2020·Development·Joana F Silva-RodriguesRita O Teodoro
Feb 26, 2020·Developmental Neurobiology·Jonas BitternChristian Klämbt
Mar 7, 2020·Developmental Neurobiology·Simone ReyChristian Klämbt
May 31, 2018·PloS One·Diana LuongJennifer C Jemc
Nov 18, 2018·Glia·Kerem YildirimChristian Klämbt
Feb 26, 2019·Proceedings of the National Academy of Sciences of the United States of America·Smita YadavYuh Nung Jan
Jul 15, 2020·International Journal of Molecular Sciences·Taejoon KimIm-Soon Lee
Mar 17, 2021·Annual Review of Neuroscience·Klaus-Armin Nave, Hauke B Werner

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