PMID: 6164683Apr 1, 1981Paper

Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systems

The Journal of Cell Biology
J H Skene, M Willard

Abstract

In an effort to determine whether the "growth state" and the "mature state" of a neuron are differentiated by different programs of gene expression, we have compared the rapidly transported (group I) proteins in growing and nongrowing axons in rabbits. We observed two polypeptides (GAP-23 and GAP-43) which were of particular interest because of their apparent association with axon growth. GAP-43 was rapidly transported in the central nervous system (CNS) (retinal ganglion cell) axons of neonatal animals, but its relative amount declined precipitously with subsequent development. It could not be reinduced by axotomy of the adult optic nerves, which do not regenerate; however, it was induced after axotomy of an adult peripheral nervous system nerve (the hypoglossal nerve, which does regenerate) which transported only very low levels of GAP-43 before axotomy. The second polypeptide, GAP-23 followed the same pattern of growth-associated transport, except that it was transported at significant levels in uninjured adult hypoglossal nerves and not further induced by axotomy. These observations are consistent with the "GAP hypothesis" that the neuronal growth state can be defined as an altered program of gene expression exemplified in ...Continue Reading

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Citations

Apr 15, 1996·Journal of Neuroscience Research·F P HamersW H Gispen
Mar 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S M Strittmatter, M C Fishman
Sep 1, 1991·Journal of Neuroscience Research·S A Mikucki, M M Oblinger
May 1, 1995·Journal of Neuroscience Research·X Lu, P M Richardson
Sep 1, 1990·Muscle & Nerve·B R Seckel
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·D HeussB Neundörfer
Jun 1, 1982·Neurochemical Research·A M Heacock, B W Agranoff
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Aug 1, 1989·Journal of Neurocytology·K AldersonA Pestronk
Feb 1, 1997·Molecular Neurobiology·S Y Fu, T Gordon
Feb 11, 1998·Molecular Neurobiology·B G Gold
Jan 1, 1992·Molecular Neurobiology·M Kanje
Jan 1, 1991·Molecular Neurobiology·W H GispenP Schotman
Jan 1, 1989·Molecular Neurobiology·C O Van HooffW H Gispen
Dec 17, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Takana KoshiKazuhisa Takahashi
May 5, 2010·Annals of Biomedical Engineering·Celinda M KofronDiane Hoffman-Kim
Nov 10, 2010·Journal of Molecular Neuroscience : MN·Lu-Ting KuoFrancesco Scaravilli
Jun 4, 1990·Brain Research·H McIntosh, D Parkinson
Feb 28, 1994·Brain Research·R G StarrH J Federoff
Apr 1, 1986·Developmental Biology·P Grant, Y Tseng

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