PMID: 1260Dec 1, 1975

Axoplasm chemical composition in Myxicola and solubility properties of its structural proteins

The Journal of Physiology
D S Gilbert

Abstract

The chemical composition of axoplasm extracted from the giant axon of Myxicola infundibulum has been analysed, and some of the factors which disperse its gel structure have been identified. 2. The axoplasm contains about 3-6% protein, and 0-12% lipid. It is isosmotic with sea water and has a pH near 7-0. 3. Inorganic ions in extracted axoplasm include: Na+, 13m-mole/kg wet wtl; K+, 280; Cl-, 24; Ca2+, 0-3; Mg2+, 3. 4. Free organic ions in axoplasm include: gly, 180 m-mole/kg wet st.; cysteic acid, 120; asp, 75; glu, 10; ala, 7; tau, 5; thr, 2; gln and ser, trace; homarine, 63; isethionate, 0. 5. The gel structure is dispersed by solutions containing 1--10 mM-Ca2+, because this ion activates an endogenous protease. The gel can also be dispersed without proteilysis by solutions containing 0-5 M-KCl, or 0-5 M guanidine hydrochloride, or 3-5 M urea, all of which break down neurofilaments. 6. It is argued that many aspects of the composition and dispersal properties of Myxicola axoplasm are similar to those in other axons.

Citations

Aug 1, 1990·Cell Calcium·N F al-Baldawi, R F Abercrombie
Dec 1, 1987·Cell Calcium·B S Donahue, R F Abercrombie
Jan 1, 1988·Cell Motility and the Cytoskeleton·A C BreuerJ M Hopkins
Aug 31, 1979·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·K A Rubinson, P F Baker
Jan 1, 1979·The Journal of Membrane Biology·B Forbush
May 25, 1979·The Journal of Membrane Biology·C S Spyropoulos
Jan 1, 1986·The Journal of Membrane Biology·L W Horn
Sep 12, 2017·Journal of Integrative Neuroscience·Suman BhatiaPrabha Sharma

Related Concepts

Axon
Calcium
Chloride Ion Level
Cysteic Acid
Protoplasm
Glycine, Sodium Hydrogen Carbonate
Hydrogen-Ion Concentration
Lipids
Magnesium
Nerve Tissue Proteins

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