Axotomy transiently down-regulates androgen receptors in motoneurons of the spinal nucleus of the bulbocavernosus

Brain Research
Jane L Lubischer, A P Arnold

Abstract

Testosterone is an important trophic factor for motoneurons in the spinal nucleus of the bulbocavernosus (SNB), and SNB motoneurons are more responsive to testosterone than are other motoneurons. Axonal injury during early postnatal life prevents the normal development of steroid-sensitivity by adult SNB motoneurons. Axonal injury also causes changes in the expression by motoneurons of a wide range of proteins, including the up-regulation of trophic factor receptors. We have used a polyclonal antibody (PG-21; G.S. Prins) to study the expression of androgen receptors in SNB motoneurons after axonal injury. PG-21 labeled motoneuronal nuclei in the lower lumbar spinal cord of rats in a pattern that matched autoradiographic reports of androgen accumulation in this region of the nervous system. A population of numerous, small cells located dorsal to the central canal also showed evidence of androgen receptor expression. Cutting the axons of SNB motoneurons in adulthood or in development caused a decrease in androgen receptor immunoreactivity in SNB motoneurons. This is the first report that a trophic factor receptor in motoneurons is down-regulated after axonal injury, and is interesting in light of reports that testosterone treatme...Continue Reading

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Citations

Sep 5, 2002·Journal of Neuroscience Research·Cynthia L JordanRobert J Handa
Dec 18, 2001·Brain Research. Brain Research Reviews·K J JonesM Damaser
May 30, 2012·Biology of Sex Differences·Ashlyn Swift-GallantD Ashley Monks
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Feb 25, 2005·Journal of Neurobiology·Jane L LubischerV Reggie Edgerton
Oct 25, 2017·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·D Ashley Monks, Melissa M Holmes

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