Aza-Macrocyclic Triphenylamine Ligands for G-Quadruplex Recognition

Chemistry : a European Journal
Isabel PontEnrique García-España

Abstract

A new series of triphenylamine-based ligands with one (TPA1PY), two (TPA2PY) or three pendant aza-macrocycle(s) (TPA3PY) has been synthesised and studied by means of pH-metric titrations, UV/Vis spectroscopy and fluorescence experiments. The affinity of these ligands for G-quadruplex (G4) DNA and the selectivity they show for G4s over duplex DNA were investigated by Förster resonance energy transfer (FRET) melting assays, fluorimetric titrations and circular dichroism spectroscopy. Interestingly, the interactions of the bi- and especially the tri-branched ligands with G4s lead to a very intense redshifted fluorescence emission band that may be associated with intermolecular aggregation between the molecule and DNA. This light-up effect allows the application of the ligands as fluorescence probes to selectively detect G4s.

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Citations

Mar 28, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Avijit Kumar DasSarah Kölsch
Nov 9, 2019·Chembiochem : a European Journal of Chemical Biology·Isabel PontEnrique García-España
May 8, 2020·Inorganic Chemistry·Juan C FríasM Teresa Albelda
Oct 23, 2020·The Journal of Physical Chemistry. B·Zhiguo WangJun-Ping Liu
Jan 13, 2022·Physical Chemistry Chemical Physics : PCCP·Estefanía Delgado-PinarJ Sérgio Seixas de Melo

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