Azapeptides as inhibitors of the hepatitis C virus NS3 serine protease

Bioorganic & Medicinal Chemistry Letters
Rumin ZhangWilliam T Windsor

Abstract

Truncation and substitution SAR studies of azapeptide-based inhibitors of the Hepatitis C virus (HCV) NS3 serine protease have been performed. These azapeptides were designed from the HCV polyprotein's NS5A-NS5B trans cleavage junction and contained an azaamino acid residue at the P1 position. These azapeptides exhibited predominantly non-acylating, competitive inhibition, contrary to classical azapeptides.

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Citations

Nov 5, 2002·Bioorganic & Medicinal Chemistry·Anja JohanssonAnders Hallberg
Mar 15, 2014·Chemical Society Reviews·Ilker AvanAlan R Katritzky
Aug 3, 2011·Future Medicinal Chemistry·Caroline ProulxWilliam D Lubell
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Jun 2, 2021·Organic Letters·Kalpita BaruahBani Kanta Sarma
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