PMID: 6163078Jan 1, 1981Paper

Azathioprine, a clastogen in human somatic cells? Analysis of chromosome damage and SCE in lymphocytes after exposure in vivo and in vitro

Mutation Research
F ApeltM Bauchinger

Abstract

Chromosomal analyses in lymphocytes of 28 patients with multiple sclerosis were carried out before, during and after Azathioprine (Aza) therapy. Only a higher incidence of gaps was found in treated patients than in a group of healthy persons but not in comparison with untreated patients. Similarly, no significant clastogenic effect was observed in vitro after short-term and long-term treatment of unstimulated and stimulated lymphocytes with concentrations of 1--100 microgram Aza per ml. Treatment of cultures with 0.0001--4.0 microgram/ml did not yield increased SCE frequencies. The absence of any significant clastogenic effect of therapeutic doses of Aza on human somatic cells is deduced from an evaluation of previously published data and from the present results.

References

Aug 1, 1977·Australian and New Zealand Journal of Medicine·G R SymingtonR P Lambert
Apr 1, 1976·Transplantation·H V PriceH Langmaid
Jan 1, 1975·Arthritis and Rheumatism·E GinzlerD Kaplan
Oct 3, 1975·Deutsche medizinische Wochenschrift·I Unglaub-LeistenJ Ring
May 25, 1973·Humangenetik·E GannerH Huber
Jan 1, 1973·Humangenetik·E V Wright, D Bates
Feb 21, 1974·Humangenetik·J van Zyl, H F Wissmüller
Mar 16, 1970·JAMA : the Journal of the American Medical Association·M B TallentJ S Najarian
Sep 1, 1970·Transplantation·M Golby
Jan 1, 1971·Humangenetik·I Emerit, R Marteau
Jan 15, 1970·International Journal of Cancer. Journal International Du Cancer·M K Jensen
Jan 1, 1968·Humangenetik·P EberleE Perings

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Citations

May 1, 1981·Mutation Research·C E Voogd
Sep 1, 1993·Mutation Research·J D TuckerA V Carrano
Feb 1, 1993·Mutation Research·L VianD Gouy
Dec 1, 1982·Mutation Research·M BauchingerE Suhr
Dec 1, 1985·Mutation Research·M Bauchinger, E Schmid
Sep 1, 1988·Mutation Research·M BauchingerH R Pfaendler
Jan 1, 1995·Mutation Research·T DuellM Bauchinger
Dec 19, 2014·Radiation Protection Dosimetry·I K KhvostunovD C Lloyd
Nov 1, 1987·Cell and Tissue Kinetics·K Miller
Dec 1, 1990·International Journal of Radiation Biology·G R RimplM Bauchinger
Nov 1, 1990·American Journal of Medical Genetics·E D'AlessandroM Prencipe
Dec 2, 2010·Social Science Quarterly·Jonathan T Rothwell, Douglas S Massey

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