PMID: 7020612Aug 1, 1981Paper

Azathioprine in rheumatoid arthritis: double-blind study of full versus half doses versus placebo

Annals of the Rheumatic Diseases
J WoodlandH L Currey

Abstract

To test whether azathioprine in effective in rheumatoid arthritis in doses smaller than those normally used the drug was tested at 2 dosage levels, 2.5 and 1.25 mg/kg/day (2.5 AZ and 1.25 AZ), against placebo under double-blind conditions over 24 weeks. Dropouts were 7 out of 15 in the 2.5 AZ group, 4 out of 14 in the 1.25 AZ group, and 2 out of 13 in the placebo group. Some significant improvement occurred in all 3 groups, including those on placebo. However, the 2.5 AZ group fared significantly better than the placebo group, while the 1.25 AZ group results tended to fall between the other 2 groups. We conclude that, in order to obtain the reported effectiveness of azathioprine in rheumatoid arthritis, it is necessary to start treatment with 2.5 mg/kg/day. Halving this dosage reduces the effectiveness of the drug.

References

Mar 1, 1977·Arthritis and Rheumatism·I L DwoshM A Ogryzlo
Apr 1, 1976·Southern Medical Journal·R CadeG Spooner
Mar 22, 1976·European Journal of Clinical Pharmacology·K M GOEBELU Börngen
May 1, 1974·Clinical Pharmacology and Therapeutics·D R Taves
Sep 28, 1974·British Medical Journal·H L CurreyB Owen-Smith
Jan 1, 1973·Arthritis and Rheumatism·J L Decker
Feb 15, 1969·British Medical Journal·M MasonI D Strickland
May 1, 1980·Rheumatology and Rehabilitation·M de SilvaJ E Dippy
Nov 1, 1962·Journal of Chronic Diseases·C R JOYCE

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Citations

Feb 13, 2002·Arthritis and Rheumatism·UNKNOWN American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines
Jan 1, 1975·Arthritis and Rheumatism·T HunterM A Ogryzlo
Sep 1, 1990·Clinical Rheumatology·A A DrososH M Moutsopoulos
Aug 14, 2003·Best Practice & Research. Clinical Rheumatology·Susan Jung-Ah Lee, Arthur Kavanaugh
Jun 1, 1994·Journal of Clinical Pharmacy and Therapeutics·N J Gittoes
Apr 1, 1993·Australian and New Zealand Journal of Medicine·P M Brooks
Oct 1, 1989·Annals of the Rheumatic Diseases·T PullarM Feely
Dec 1, 1990·Baillière's Clinical Rheumatology·R A LuqmaniP A Bacon
Jul 13, 2016·Drugs & Aging·Su-Ann YeohRichard Hull
Dec 30, 1983·The American Journal of Medicine·J L Decker
Oct 18, 2000·The Cochrane Database of Systematic Reviews·M E Suarez-AlmazorE Belseck
Oct 10, 2020·Nature Reviews. Disease Primers·Emanual MaverakisSinéad M Langan
Oct 1, 1991·Seminars in Arthritis and Rheumatism·W S Wilke, J D Clough

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