Azathioprine is effective in corticosteroid-dependent Asian inflammatory bowel disease patients

Inflammatory Bowel Diseases
Kelvin T ThiaChoon-Jin Ooi

Abstract

Azathioprine (AZA) is widely used to treat corticosteroid (CS)-dependent IBD patients but evidence supporting its use in Asian IBD patients is limited. We evaluated the efficacy of AZA in a single-center cohort of CS-dependent Asian IBD patients. Patients treated with AZA were identified from our registry and the medical records were reviewed. Inclusion criterion was: first course of AZA and treatment duration ≥ 6 months. Clinical response was assessed at 6 months and classified as complete response, partial response, and nonresponse. Factors associated with response (age, gender, ulcerative colitis [UC] extent, Crohn's disease [CD] behavior, ethnicity, concomitant 5-aminosalicylates/sulfasalazine, baseline activity, disease duration, leukocyte count, mean corpuscular volume, and AZA dose) were analyzed using the chi-square or Mann-Whitney U-test. Probability of sustained remission was estimated using the Kaplan-Meier method. Differences in survival curves between factors were tested with log-rank tests. Sixty-four patients were included. At baseline the median age was 37.5 (range, 15-76) years, 50% male, 59.4% Chinese, 50% CD, 50% UC, and mean CS dose 20.2 (SD 10.9) mg. At month 6, complete response was 48.4% (95% confidence i...Continue Reading

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Citations

Sep 28, 2013·Journal of Translational Medicine·Jianghong WuShudong Xiao
Mar 9, 2012·Journal of Crohn's & Colitis·Giuseppe CostantinoWalter Fries
Nov 8, 2011·Digestive Diseases and Sciences·Jae Jun ParkWon Ho Kim
Apr 5, 2011·Journal of Zhejiang University. Science. B·Ning ZhouYou-ming Li
Jun 4, 2016·European Journal of Gastroenterology & Hepatology·Romein W G DujardinMark Löwenberg
Dec 23, 2017·Inflammatory Bowel Diseases·Sara van GennepMark Löwenberg
Jul 13, 2019·Current Opinion in Pharmacology·Yasmin SchmidSimon M Mueller
Mar 23, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan-Feng HuangYou-Liang Xie

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