Azelastine and suplatast shorten the distribution half-life of IgE in rats

Mediators of Inflammation
K HanashiroTadayoshi Kosugi

Abstract

We aim to clarify whether suplatast and azelastine (anti-allergic drugs) can shorten the half-life of imnunoglobulin E (IgE) in the circulating blood. Thirty Wistar rats were divided into six groups. Distilled water or anti-allergic drugs were given orally for 6 days after the first sensitization. Two milligrams of monoclonal dinitrophenyl (DNP)-specific rat IgE was administered to the rats, which had been given suplatast or azelastine orally. The level of DNP-specific rat IgE in the serum was estimated by IgE-capture enzyme-linked immunosorbent assay, and the turnover of IgE was analyzed from its pharmacokinetic parameters. The elimination half-life of rat IgE was about 12 h irrespective of the sensitized state. The intercompartmental rate constants (Kct and Ktc) in the suplatast-administered or azelastine-administered group were larger than those of the distilled water-administered group under non-sensitized conditions. These findings suggested that the anti-allergic drugs used in the present study facilitated the excretion of IgE from the circulation in rats.

References

Jan 1, 1975·International Archives of Allergy and Applied Immunology·T TadaH Bazin
Nov 1, 1995·International Archives of Allergy and Immunology·S KonnoM Adachi
Oct 2, 2001·Mediators of Inflammation·K HanashiroT Kosugi

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Citations

Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Manish PatelFoo Y Liew

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