Azetidine-2-carboxylic acid in garden beets (Beta vulgaris)

Phytochemistry
Edward RubensteinChristopher H Becker

Abstract

Azetidine-2-carboxylic acid (L-Aze) is a toxic and teratogenic non-protein amino acid. In many species, including man, L-Aze is misincorporated into protein in place of proline, altering collagen, keratin, hemoglobin, and protein folding. In animal models of teratogenesis, it causes a wide range of malformations. The role of L-Aze in human disease has been unexplored, probably because the compound has not been associated with foods consumed by humans. Herein we report the presence of L-Aze in the garden or table beet (Beta vulgaris).

References

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Citations

Jun 20, 2013·Applied Microbiology and Biotechnology·Thi Mai Hoa Bach, Hiroshi Takagi
Oct 30, 2008·Journal of Neuropathology and Experimental Neurology·Edward Rubenstein
Dec 23, 2008·Phytochemistry·Edward RubensteinAllis Chien
Jan 1, 2014·Experimental Neurology·Kenneth J Rodgers
Jun 21, 2020·Antibiotics·Muhammad IdreesAyesha Rahman
Oct 22, 2020·G3 : Genes - Genomes - Genetics·Matthew D BergChristopher J Brandl
Jan 27, 2021·Proteomes·Joel R SteeleMatthew P Padula
Feb 22, 2021·The Journal of Biological Chemistry·Anutthaman ParthasarathyAndré O Hudson

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