Azide-rich peptides via an on-resin diazotransfer reaction

Biopolymers
Jeannette E MarineJonathan G Rudick

Abstract

Azide-containing amino acids are valuable building blocks in peptide chemistry, because azides are robust partners in several bioorthogonal reactions. Replacing polar amino acids with apolar, azide-containing amino acids in solid-phase peptide synthesis can be tricky, especially when multiple azide residues are to be introduced in the amino acid sequence. We present a strategy for effectively incorporating multiple azide-containing residues site-specifically.

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Citations

Dec 18, 2015·Biomacromolecules·Jeannette E MarineJonathan Gallagher Rudick
Aug 14, 2015·Chemical Communications : Chem Comm·Jeannette E MarineJonathan G Rudick
Mar 30, 2019·Polymer Chemistry·Deborah A BarkleyJonathan G Rudick

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