PMID: 7029257May 1, 1981Paper

Azido analogs of acridine: photoaffinity probes for frameshift mutagenesis in Salmonella typhimurium

Mutation Research
W J FirthL W Yielding

Abstract

In order to identify a photoaffinity probe for 9-aminoacridine frameshift mutagenesis, 20 azido analogs of acridine were synthesized and tested in Ames' Salmonella tester strains, TA1535, TA1537, TA1538 and their corresponding excision-repair-coefficient strains TA1975, TA1977 and TA1978, to determine their mutagenicity and toxicity relative to 9-aminoacridine. The substituent-mutagenicity patterns observed for these compounds agree very well with those obtained previously for non-azidoacridines. The results presented here show that the 2-azido-analog of 9-aminoacridine demonstrates biological activity similar to 9-aminoacridine prior to photolytic activation. With light activation, however, the 9-amino-2-azido derivative becomes more effective at producing frameshift mutations characteristic of 9-aminoacridine. Furthermore, this photolytic enhancement of mutagenesis appears to be due to the repairable lesion suggesting that covalent attachment of the drug occurs.

References

Dec 1, 1979·Mutation Research·A Nasim, T Brychcy
Mar 30, 1979·Biochemical and Biophysical Research Communications·L W YieldingK L Yielding
Jan 1, 1976·Annual Review of Biochemistry·J W Drake, R H Baltz
Nov 2, 1977·Biochimica Et Biophysica Acta·D E GravesK L Yielding
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesF D Lee
Mar 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·W E Durston, B N Ames
Nov 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·B N AmesH Bartsch
Mar 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesW E Durston
Aug 1, 1980·Mutation Research·B R BrownL W Yielding

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Citations

Feb 1, 1988·Mutation Research·W M Owais, A Kleinhofs
Jul 26, 2017·EFSA Journal·UNKNOWN European Food Safety Authority (EFSA)Marco Binaglia

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