Jun 9, 2020Paper

Azithromycin and ciprofloxacin have a chloroquine-like effect on respiratory epithelial cells

BioRxiv : the Preprint Server for Biology
Jens F PoschetVojo Deretic

Abstract

There is interest in the use of chloroquine/hydroxychloroquine (CQ/HCQ) and azithromycin (AZT) in COVID-19 therapy. Employing cystic fibrosis respiratory epithelial cells, here we show that drugs AZT and ciprofloxacin (CPX) act as acidotropic lipophilic weak bases and confer in vitro effects on intracellular organelles similar to the effects of CQ. These seemingly disparate FDA-approved antimicrobials display a common property of modulating pH of endosomes and trans-Golgi network. We believe this may in part help understand the potentially beneficial effects of CQ/HCQ and AZT in COVID-19, and that the present considerations of HCQ and AZT for clinical trials should be extended to CPX.

Citations

Aug 28, 2020·Expert Review of Anti-infective Therapy·Daniel Echeverría-EsnalSantiago Grau
Jul 29, 2020·International Journal of Molecular Sciences·Rami A Al-HoraniKholoud F Aliter
Sep 6, 2020·Pharmacological Reports : PR·Thakur Uttam SinghRaj Kumar Singh
May 14, 2020·BJGP Open·Kome Gbinigie, Kerstin Frie
Oct 10, 2020·The Protein Journal·Siddhi TandonSarika Chaudhary
Feb 16, 2021·World Journal of Virology·Asim KichlooAkif Kichloo
Mar 31, 2021·Virology Journal·Zachary A KrummYuxing Xia
May 1, 2021·International Journal of Molecular Sciences·Gustavo José da Silva PereiraClaudia Bincoletto
May 4, 2021·Frontiers in Medicine·Gaber El-Saber BatihaHelal F Hetta
May 13, 2021·Expert Review of Respiratory Medicine·Mario CazzolaMaria Gabriella Matera

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