PMID: 9425251Mar 14, 1998Paper

Azithromycin and clarithromycin inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells

Current Microbiology
W S Champney, R Burdine

Abstract

The ID50 values for azithromycin and clarithromycin inhibition of translation and of 50S assembly in Staphylococcus aureus cells have been measured. For clarithromycin, 50% inhibition of growth occurred at 0.075 microg/ml, and the effects on translation and 50S formation were equivalent at 0.15 microg/ml. The inhibition of these processes by azithromycin was less effective, with an ID50 of 2.5 microg/ml for growth and 5 microg/ml for inhibition of translation and 50S formation. The additive effects of each of these drugs on translation and 50S formation account quantitatively for their observed influence on cellular growth rates. In macrolide-treated cells, there was also a direct relationship between the loss of ribosomal RNA from the 50S subunit and its accumulation as oligoribonucleotides. These results are compared with the previously described effects of erythromycin on these same processes.

Citations

Mar 4, 2000·Journal of Pharmaceutical and Biomedical Analysis·B Lingerfelt, W S Champney
Jun 13, 2001·Molecular Microbiology·J Usary, W S Champney
Nov 18, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·W S Champney, R Burdine
Jun 15, 2007·Antimicrobial Agents and Chemotherapy·W Scott Champney, Ward K Rodgers
Apr 18, 2002·Antimicrobial Agents and Chemotherapy·Roopal Mehta, W Scott Champney
Mar 5, 2009·Microbiology and Molecular Biology Reviews : MMBR·Bruce A Maguire
Feb 27, 2003·American Journal of Veterinary Research·Rob L CokeJames W Carpenter
Apr 2, 2003·Journal of Veterinary Pharmacology and Therapeutics·R P HunterR Isaza
Mar 19, 2014·Pharmacology & Therapeutics·Michael J ParnhamRobin Vos
Nov 18, 2015·Nature Chemical Biology·Jonathan M Stokes, Eric D Brown
Dec 21, 2019·Journal of Cataract and Refractive Surgery·Kazuichi MaruyamaKohji Nishida
Jan 17, 2020·The Journal of Antimicrobial Chemotherapy·W Scott Champney
Feb 11, 2005·Chemical Reviews·Leonard Katz, Gary W Ashley
Jul 3, 2021·Cancers·Christina PfabNahed El-Najjar

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