PMID: 9175650May 1, 1997Paper

Azithromycin and erythromycin resistant Neisseria gonorrhoeae following treatment with azithromycin

International Journal of STD & AIDS
H YoungA McMillan

Abstract

A pre-treatment and a 3-week post-treatment isolate of Neisseria gonorrhoeae from a 13-year-old boy treated with azithromycin in a single 1 g oral dose were characterized microbiologically. Both isolates were of the same serovar/auxotype (1B6/non-requiring) and had similar antibiograms apart from erythromycin and azithromycin: the pre- and post-treatment MICs (minimum inhibitory concentrations) were: 1 mg/L and 32 mg/L to erythromycin and 0.125 mg/L and 3 mg/L to azithromycin. The finding that both isolates were 1B6/NR, had similar antibiograms (other than azithromycin and erythromycin), and no other 1B6/NR isolates were resistant to erythromycin supports the view that macrolide resistance developed following treatment. A high overall level of azithromycin susceptibility was confirmed by testing 67 clinical isolates: MIC90 0.5 mg/L (range 0.023-0.75 mg/L). We conclude that the long half-life of azithromycin which is beneficial in treating chlamydial infection may result in increased selective pressure for resistance in gonococci. This report also highlights the importance of antibiotic susceptibility surveillance of gonococci and stresses the need for appropriate treatment of gonococcal infection, particularly when it is prescr...Continue Reading

Citations

Apr 17, 2012·Sexually Transmitted Diseases·Philippe R S Lagace-WiensSupriya D Mehta
May 27, 2009·The Journal of Antimicrobial Chemotherapy·S A ChisholmC A Ison
May 31, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M EndersT Regnath
Oct 12, 2010·Journal of Global Infectious Diseases·Manju Bala, Seema Sood
Sep 5, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan A WangHillard S Weinstock
Mar 8, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lori M NewmanKimberly A Workowski
Feb 7, 2002·Expert Opinion on Pharmacotherapy·John Tapsall
Nov 26, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sarah Kidd, Kimberly A Workowski
Jan 21, 2006·Diagnostic Microbiology and Infectious Disease·Sudha PottumarthyRonald N Jones
Mar 14, 2014·Sexually Transmitted Diseases·Judith VandepitteDavid A Lewis
Oct 15, 2011·International Journal of STD & AIDS·C BignellUNKNOWN British Association for Sexual Health and HIV UK
Jan 9, 2014·International Journal of STD & AIDS·C BignellUNKNOWN European STI Guidelines Editorial Board
Jun 23, 2009·International Journal of STD & AIDS·C Bignell, UNKNOWN IUSTI/WHO
Dec 19, 1998·Sexually Transmitted Diseases·J W TapsallB P Mulhall
Aug 24, 2001·Sexually Transmitted Diseases·J A DillonUNKNOWN Caribbean GASP Network. Gonococcal Antimicrobial Surveillance Program
Jul 2, 2014·Clinical Microbiology Reviews·Magnus Unemo, William M Shafer
Mar 31, 2006·Sexually Transmitted Diseases·Michael DanTamy Shohat
May 18, 2019·Health Technology Assessment : HTA·Jonathan Dc RossTessa Lawrence
Nov 28, 2013·Current Opinion in Infectious Diseases·David A Lewis
Jun 18, 2019·Sexual Health·Sarah Mensforth, Jonathan D C Ross
Mar 10, 2019·International Journal of Audiology·Andrew Stuart, Hannah M Nelson
Sep 21, 2017·Emerging Infectious Diseases·Robert D KirkcaldyLauri A Hicks
May 17, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carolien M WindHenry J C de Vries

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.