Azithromycin as prophylaxis for the prevention of postoperative infection in impacted mandibular third-molar surgery

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
Kohji IshihamaYukihiro Ota

Abstract

Rotational use of antimicrobials is one of the strategies that have been suggested to reduce the development of drug-resistant bacteria. Cycling of homogeneous antimicrobial exposure is, however, unlikely to control the emergence of antimicrobial resistance. Penicillins and cephalosporins have been extensively used for therapeutic and prophylactic management of oral infection. The aim of the study was to investigate the clinical effects of azithromycin as prophylaxis on the prevention of postoperative infection in impacted mandibular third-molar surgery. The study design was a retrospective, single-center review. One (2.2%) of all 45 patients exhibited dry socket infection. In several categories, there was significant effectiveness of azithromycin in comparison with other antimicrobials, although there was no significant difference in the occurrence rate of dry socket infection. Azithromycin might be of value for prophylactic use in impacted mandibular third-molar surgery in which penicillins and cephalosporins were mainly used. Therefore, it might be available for one of the rotational agents.

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Citations

Jan 17, 2014·Journal of Maxillofacial and Oral Surgery·Vikrant Dilip SaneRajshekhar Halli
Apr 9, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Jeffrey A EloHardev M Singh
Jan 14, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jacobo LimeresPedro Diz
Apr 22, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Rui FigueiredoCosme Gay-Escoda
Apr 10, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Adriana M CalvoCarlos F Santos
Aug 9, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Eva RamosIcíar Arteagoitia
Jul 3, 2018·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Mohammad Ali SaghiriNader Sheibani

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