Azithromycin extended release vs amoxicillin/clavulanate: symptom resolution in acute sinusitis

American Journal of Otolaryngology
Bradley F MarpleSonia P Sanchez

Abstract

The aim of the study was to compare early symptom resolution with a single 2-g dose of azithromycin extended release or 10 days of amoxicillin/clavulanate 875 mg/125 mg every 12 hours in patients with acute sinusitis. This was a prospective, randomized, open-label, observational study to mimic "real-world" conditions, including patients with symptoms of acute bacterial sinusitis lasting between 7 and 30 days. Key symptoms were assessed twice daily by patient diary, and patients were interviewed by telephone at 12 and 28 days. The primary end point was symptom resolution at 5 days, defined as reporting "no problem" with at least 3 of 4 diary symptoms in 2 consecutive measures in the per-protocol population. Secondary end points included additional antibiotic use, sinusitis-related quality of life, and treatment satisfaction. Three hundred seventy-eight patients were randomized to a single dose of azithromycin extended release and 371 to 10 days of amoxicillin/clavulanate. In the per-protocol population at day 5, 70/236 patients (29.7%) in the azithromycin extended release arm and 45/238 patients (18.9%) in the amoxicillin/clavulanate arm had resolution of symptoms (difference = 10.8%; 95% confidence interval [CI], 3.1-18.4%). By...Continue Reading

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Citations

Mar 1, 2012·Journal of Comparative Effectiveness Research·Don P BueschingMarc L Berger
Mar 19, 2014·Pharmacology & Therapeutics·Michael J ParnhamRobin Vos
Jun 30, 2011·Medical Decision Making : an International Journal of the Society for Medical Decision Making·David O MeltzerAnirban Basu
Oct 17, 2015·The Cochrane Database of Systematic Reviews·Anneli Ahovuo-SalorantaMarjukka Mäkelä
Jan 15, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery

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