Azithromycin in the Treatment of Preterm Prelabor Rupture of Membranes Demonstrates a Lower Risk of Chorioamnionitis and Postpartum Endometritis with an Equivalent Latency Period Compared with Erythromycin Antibiotic Regimens.

Infectious Diseases in Obstetrics and Gynecology
Daniel MartinganoAntonina Mitrofanova

Abstract

To determine if antibiotic regimens including azithromycin versus erythromycin has an impact on pregnancy latency and development of clinical chorioamnionitis in the context of preterm prelabor rupture of membranes. Study Design. We conducted a prospective observational cohort study and followed all women receiving antibiotic regimens including either azithromycin or erythromycin in the context of preterm prelabor rupture of membranes. Primary outcomes were the duration of pregnancy latency period and development of chorioamnionitis. Secondary outcomes included neonatal sepsis with positive blood culture, cesarean delivery, postpartum endometritis, and meconium-stained amniotic fluid. This study included 310 patients, with 142 receiving the azithromycin regimen and 168 receiving the erythromycin regimen. Patients receiving the azithromycin regimen had a statistically significant advantage in overall rates of clinical chorioamnionitis (13.4% versus 25%, p = 0.010), neonatal sepsis (4.9% versus 14.9%, p = 0.004), and postpartum endometritis (14.8% versus 31%, p = 0.001). In crude and adjusted models, when comparing the azithromycin group with the erythromycin group, a decreased risk was noted for the development of clinical chori...Continue Reading

References

Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
Mar 4, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gian Carlo Di RenzoYves Ville
Apr 22, 2011·Clinical Obstetrics and Gynecology·Thaddeus P Waters, Brian Mercer
Aug 28, 2014·Obstetrics and Gynecology·Rebecca C PiersonDavid M Haas
Feb 9, 2016·Obstetrics and Gynecology·Rosemary D HigginsUNKNOWN Chorioamnionitis Workshop Participants
Mar 25, 2019·American Journal of Obstetrics and Gynecology·Reshama NavatheAmanda Roman

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Citations

May 9, 2021·American Journal of Obstetrics and Gynecology·Metabel T MarkweiOluwatosin Goje

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