Azlactone-Functionalized Polymers as Reactive Platforms for the Design of Advanced Materials: Progress in the Last Ten Years

Polymer Chemistry
Maren E Buck, David M Lynn

Abstract

Polymers functionalized with azlactone (or oxazolone) functionality have become increasingly useful for the rapid and modular design of functional materials. Because azlactones can react via ring-opening reactions with a variety of different nucleophilic species (e.g., primary amines, hydroxyl groups, and thiol functionality), azlactone-functionalized materials can serve as convenient 'reactive' platforms for the post-synthesis or post-fabrication introduction of a broad range of chemical functionality to soluble polymers, insoluble supports, and surfaces/interfaces. The last decade has seen an increase in both the number and the variety of reports that exploit the properties and the reactivities of azlactone-functionalized polymers. Here, we highlight recent work from several different laboratories, including our own, toward the design and characterization of azlactone-functionalized polymers, with a particular emphasis on: (i) new synthetic approaches for the preparation of well-defined azlactone-functionalized polymers using living/controlled methods of polymerization, (ii) the design and modular synthesis of side-chain functionalized polymers and block copolymers via post-polymerization modification of azlactone-functionali...Continue Reading

References

Jun 5, 1998·Biomaterials·A Curtis, C Wilkinson
Jul 20, 2004·Angewandte Chemie·Claire S Peyratout, Lars Dähne
Feb 24, 2005·Chemical Society Reviews·Nicole K Boaen, Marc A Hillmyer
Oct 30, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Sean P CullenPadma Gopalan
Nov 11, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Michael I KinsingerNicholas L Abbott
Dec 2, 2008·Angewandte Chemie·Marc A GauthierHarm-Anton Klok
Jan 1, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Joshua E BarringerS Michael Kilbey
Jan 15, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sharon Y WongDavid Putnam
Feb 23, 2010·Carbohydrate Research·Céline LucchesiGilles Dujardin
Mar 11, 2010·Advanced Materials·Thomas BoudouCatherine Picart
Mar 12, 2010·Chemical Communications : Chem Comm·Damian ConnollyBrett Paull
Apr 22, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Michael I KinsingerDavid M Lynn
Aug 4, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Bin Sun, David M Lynn
Dec 7, 2010·Angewandte Chemie·Christopher Barner-KowollikWim Van Camp
Dec 15, 2010·Chemistry of Materials : a Publication of the American Chemical Society·Maren E BuckDavid M Lynn

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Citations

Apr 21, 2018·Macromolecular Rapid Communications·Marcel EnkeUlrich S Schubert
May 23, 2015·Advanced Healthcare Materials·Samantha K SchmittPadma Gopalan
Jul 13, 2012·Macromolecular Rapid Communications·Hien The HoLaurent Fontaine
Apr 18, 2012·Macromolecular Rapid Communications·Aurélie LaquièvreDavid Fournier
Jul 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiqi ZhangYen Wei
Feb 15, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alireza KavandDelphine Chan-Seng
May 4, 2021·Chemical Reviews·Ramya KumarTheresa M Reineke
Jan 10, 2020·Chemical Science·Jiaming ZhuangS Thayumanavan
Aug 16, 2014·Accounts of Chemical Research·Rachelle M ArnoldJason Locklin
Jun 27, 2012·Journal of the American Chemical Society·Guillaume GodySébastien Perrier
Sep 1, 2016·ACS Applied Materials & Interfaces·Shunjie YanJinghua Yin
Jul 25, 2019·Biomacromolecules·Xuanrong GuoDavid M Lynn
Nov 13, 2015·ACS Applied Materials & Interfaces·Xuanrong GuoDavid M Lynn

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