PMID: 677860Jun 1, 1978

Azlocillin and mezlocillin: new ureido penicillins

Antimicrobial Agents and Chemotherapy
K P Fu, H C Neu

Abstract

The activity of azlocillin and mezlocillin, new semisynthetic ureido penicillins, was investigated and compared with that of other known beta-lactam antibiotics. At a concentration of 25 mug/ml, azlocillin inhibited 74% of Enterobacter, 97% of Proteus mirabilis, 64% of Citrobacter, 91% of Pseudomonas aeruginosa, and 82% of Bacteroides strains tested. Mezlocillin inhibited 86% of Shigella, 96% of Enterobacter, 80% of indole-positive Proteus, 88% of Bacteroides, and 63% of Pseudomonas strains tested. Azlocillin was more active against Pseudomonas than was ticarcillin, carbenicillin, or mezlocillin. Mezlocillin was more active than carbenicillin and ampicillin against Escherichia coli, Klebsiella, Enterobacter, Citrobacter, Acinetobacter, Serratia, and Bacteroides. Azlocillin and mezlocillin were less active than cefazolin against beta-lactamase-producing E. coli and Klebsiella strains but more active than cefazolin against Enterobacter, indole-positive Proteus, Acinetobacter, Citrobacter, and Serratia strains. Both compounds showed activity equivalent to that of cefoxitin against Bacteroides isolates. Both agents were destroyed by many of the beta-lactamases from gram-negative organisms.

References

Sep 1, 1976·Antimicrobial Agents and Chemotherapy·K P Fu, H C Neu
Sep 1, 1976·Antimicrobial Agents and Chemotherapy·K P Fu, H C Neu
Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C E Buchanan, J L Strominger
Oct 1, 1975·Antimicrobial Agents and Chemotherapy·H C Neu, G J Garvey
Aug 8, 1974·The New England Journal of Medicine·C H BrownC P Alfrey
Feb 1, 1972·Antimicrobial Agents and Chemotherapy·R B Sykes, K Nordström
May 1, 1973·Annals of Internal Medicine·J KlasterskyM Mathiew
Aug 1, 1970·Archives of Biochemistry and Biophysics·H C Neu, E B Winshell

Citations

Jan 1, 1982·European Journal of Clinical Pharmacology·G R AronoffN S Fineberg
Jan 1, 1982·European Journal of Clinical Pharmacology·U Gundert-Remy, E Weber
Jan 1, 1980·Infection·R Roos, W Marget
Mar 1, 1979·Antimicrobial Agents and Chemotherapy·L Coppens, J Klastersky
Jul 1, 1980·Antimicrobial Agents and Chemotherapy·A R WhiteR Sutherland
Aug 1, 1980·Antimicrobial Agents and Chemotherapy·J C WadeP H Wiernik
Aug 1, 1981·Antimicrobial Agents and Chemotherapy·P C FuchsE H Gerlack
Oct 1, 1984·Antimicrobial Agents and Chemotherapy·M B BansalH Thadepalli
May 1, 1989·Antimicrobial Agents and Chemotherapy·R D LanderD R Pyszczynski
May 28, 1983·British Medical Journal·C R Pennington, J Crooks
Jan 1, 1986·Scandinavian Journal of Infectious Diseases·C E NordS Aase
Mar 25, 1999·Mayo Clinic Proceedings·A J Wright
Sep 1, 1987·Journal of Clinical Pharmacology·B R MeyersS Z Hirschman
Feb 8, 1985·The American Journal of Medicine·J D Allan, R C Moellering
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Feb 18, 1988·The New England Journal of Medicine·G R Donowitz, G L Mandell
Nov 1, 1982·Pharmacotherapy·R V McCloskeyG R Aronoff
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