PMID: 3581029Jul 1, 1987

Azlocillin, cephalothin, and tobramycin therapy in febrile solid tumor patients with chemotherapy-induced leukopenia

Cancer
S LowenbraunD Cunitz

Abstract

Although the semisynthetic broad-spectrum acylureido-penicillin, azlocillin has been demonstrated to have significant antibiotic activity in leukemic patients, its role in combination therapy of febrile granulocytopenic patients with chemotherapy-treated solid tumors has not been clearly delineated. Thirty-five solid tumor patients with chemotherapy-induced absolute granulocytopenia (less than 1000 granulocytes/ml) associated with fever (greater than 38.3 degrees C) were treated on a prospective study with a combination of azlocillin 4 g intravenously (IV) every 6 hours, cephalothin 2 g IV every 6 hours, and tobramycin 80 to 100 mg IV every 8 to 12 hours. Prior chemotherapy included doxorubicin combinations in 18 patients and other combinations in 17 patients. Granulocyte counts preantibiotic therapy were greater than 100 granulocyte/ml in 14 patients, 100 to 499 in nine patients, and 500 to 1000 in 12 patients. Granulocyte nadirs were less than 100 in 20 patients, 100 to 499 in nine patients, and 500 to 1000 in six patients. Times for granulocytes to rise towards normal were 1 to 3 days in eight patients, 4 to 6 days in 18 patients, and 7 or more days in nine patients. Tobramycin levels were primarily in the peak range of 3 to...Continue Reading

References

Dec 1, 1995·Neurosurgery·K A WalterH Brem
Jul 18, 2001·Chemical & Pharmaceutical Bulletin·C ZhangF Jin
Apr 4, 2003·Chemical & Pharmaceutical Bulletin·Sung-Ryong KoYukio Suzuki

Citations

Jun 1, 1978·Antimicrobial Agents and Chemotherapy·K P Fu, H C Neu
Dec 1, 1972·Antimicrobial Agents and Chemotherapy·J KlasterskyD Daneau
Nov 1, 1982·Annals of Internal Medicine·G M Eliopoulos, R C Moellering
Jan 1, 1984·Reviews of Infectious Diseases·G L DrusanoW L Hewitt
May 1, 1983·The Journal of Antimicrobial Chemotherapy·N X Chin, H C Neu
May 1, 1983·The Journal of Antimicrobial Chemotherapy·H Grimm
May 1, 1983·The Journal of Antimicrobial Chemotherapy·M F Parry
May 1, 1983·The Journal of Antimicrobial Chemotherapy·C C Sanders
May 1, 1983·The Journal of Antimicrobial Chemotherapy·P SchachtD Tettenborn
May 1, 1983·The Journal of Antimicrobial Chemotherapy·M F Parry
May 1, 1980·The American Journal of Medicine·L J LoveP H Wiernik

Related Concepts

Doxorubicin
Pathogenic Organism
Granulocyte Count
Polychemotherapy
Azlin
Adverse Effects
Hairy Cell Leukemia
Leukopenia
Ceftina
Drug Evaluation

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.