Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria.

Antimicrobial Agents and Chemotherapy
R B SykesN H Georgopapadakou

Abstract

Azthreonam (SQ 26,776) is a synthetic monocyclic beta-lactam antimicrobial agent belonging to the monobactam family (Sykes et al., Nature [London] 291:489-491, 1981), members of which are characterized by having the 2-oxoazetidine-1-sulfonic acid moiety. Azthreonam exhibits a high degree of stability to beta-lactamases and is specifically active against aerobic gram-negative bacteria, including Pseudomonas aeruginosa. Its activity against these organisms was in general equal or superior to that observed with the third-generation cephalosporins, cefotaxime and ceftazidime. Like penicillins and cephalosporins, azthreonam interacts with essential penicillin-binding proteins of gram-negative bacteria. Azthreonam protected mice against experimental infections produced by a range of gram-negative bacteria, exhibiting efficacy comparable to that of cefotaxime and ceftazidime.

References

Jul 1, 1979·The Journal of Antimicrobial Chemotherapy·M Matthew
Jun 1, 1976·The Journal of Antimicrobial Chemotherapy·R B Sykes, M Matthew
Jun 6, 1973·Biochimica Et Biophysica Acta·G W Ross, M G Boulton
Jul 1, 1974·European Journal of Biochemistry·W M Bonner, R A Laskey
Jun 1, 1974·The Biochemical Journal·R Eisenthal, A Cornish-Bowden
Jun 11, 1981·Nature·R B SykesJ S Wells
Jul 1, 1980·Antimicrobial Agents and Chemotherapy·N H Georgopapadakou, F Y Liu

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Citations

Dec 1, 1987·European Journal of Clinical Microbiology·M R MillarP Congdon
Dec 15, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G LiX Jiang
Jan 1, 1985·Pharmacology & Therapeutics·R B SykesE A Swabb
Jul 1, 1983·The Journal of Pediatrics·M I Marks
Sep 30, 2000·Bioorganic & Medicinal Chemistry Letters·E B GrantD J Hlasta
May 1, 2010·Nature Reviews. Drug Discovery·Brian P O'SullivanPeter Kirkpatrick
Dec 8, 2010·Proceedings of the National Academy of Sciences of the United States of America·Seungil HanVeerabahu Shanmugasundaram
Mar 29, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·C UrbanJ J Rahal
Jun 27, 2007·Antimicrobial Agents and Chemotherapy·Anne Marie QueenanKaren Bush
Sep 29, 2006·Antimicrobial Agents and Chemotherapy·Anne Marie QueenanJohn Quinn
Jun 1, 1982·Antimicrobial Agents and Chemotherapy·N H GeorgopapadakouR B Sykes
Sep 1, 1982·Antimicrobial Agents and Chemotherapy·K BushR B Sykes
Oct 1, 1982·Antimicrobial Agents and Chemotherapy·H MikamiS Mitsuhashi
Jan 1, 1983·Antimicrobial Agents and Chemotherapy·E A SwabbD N McKinstry
Apr 1, 1983·Antimicrobial Agents and Chemotherapy·A JafféE Derlot
Jun 1, 1983·Antimicrobial Agents and Chemotherapy·F G PilkiewiczR B Sykes
Jul 1, 1983·Antimicrobial Agents and Chemotherapy·B E ScullyH C Neu
Aug 1, 1983·Antimicrobial Agents and Chemotherapy·J C MihinduW K Bolton
Nov 1, 1983·Antimicrobial Agents and Chemotherapy·W M ScheldG Rodeheaver
Jan 1, 1984·Antimicrobial Agents and Chemotherapy·N F AdkinsonA A Sugerman
Feb 1, 1984·Antimicrobial Agents and Chemotherapy·D M LivermoreJ D Williams
Mar 1, 1984·Antimicrobial Agents and Chemotherapy·Y SainoS Mitsuhashi
Mar 1, 1984·Antimicrobial Agents and Chemotherapy·S A LukehartK K Holmes
Aug 1, 1984·Antimicrobial Agents and Chemotherapy·S M SinghviB H Migdalof
Aug 1, 1984·Antimicrobial Agents and Chemotherapy·H R StutmanE A Swabb
Aug 1, 1984·Antimicrobial Agents and Chemotherapy·H GiamarellouG K Daikos
Oct 1, 1984·Antimicrobial Agents and Chemotherapy·P G JonesJ Pasternak
Oct 1, 1984·Antimicrobial Agents and Chemotherapy·D H WuP E Conley
Feb 1, 1985·Antimicrobial Agents and Chemotherapy·D L BechardL T Friedhoff
Apr 1, 1985·Antimicrobial Agents and Chemotherapy·K BushR B Sykes
Apr 1, 1985·Antimicrobial Agents and Chemotherapy·G H McCrackenK D Olsen
Feb 1, 1986·Antimicrobial Agents and Chemotherapy·D PierardS Lauwers
Jun 1, 1986·Antimicrobial Agents and Chemotherapy·R E CondonB Levinson

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