PMID: 3766490Nov 1, 1986Paper

Aztreonam therapy for serious gram-negative infections in children

American Journal of Diseases of Children
H R StutmanM I Marks

Abstract

Fifty-nine children were enrolled in an open trial of aztreonam, a monocyclic beta-lactam, therapy for serious gram-negative infections. Thirty-six infections were microbiologically evaluable and received five or more days of therapy. Patients' ages ranged from 3 days to 12 years, and diagnoses included pyelonephritis or cystitis (20), deep soft tissue or joint infection (seven), septicemia (four), pneumonia (three), peritonitis, and epiglottitis. Causative bacteria included Escherichia coli and other Enterobacteriaceae, Pseudomonas aeruginosa, and Haemophilus influenzae. The standard regimen was 30 mg/kg every six or eight hours intravenously. All isolates were aztreonam-susceptible and were eradicated during therapy. Two patients had microbiologic relapses: a patient with Salmonella choleraesuis meningitis who was initially treated for only ten days and a patient with E coli pyelonephritis. Clinical cure was achieved in 31 of 36 children. Pharmacokinetic studies performed in six children demonstrated no difference in serum concentrations or pharmacokinetic variables between day 1 and day 7 of therapy. Although several patients had transient eosinophilia (eight), elevated levels of aminotransferase (seven), or thrombocytosis (...Continue Reading

Citations

Jun 1, 1990·Antimicrobial Agents and Chemotherapy·H SakataH Yoshioka
Dec 1, 1987·European Journal of Clinical Microbiology·M R MillarP Congdon
Jan 12, 2011·Journal of Veterinary Pharmacology and Therapeutics·J A Paxson, M R Paradis
Jun 15, 1997·Cellular Immunology·M L Thoman

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