Azuki bean (Vigna angularis) extract reduces oxidative stress and stimulates autophagy in the kidneys of streptozotocin-induced early diabetic rats

Canadian Journal of Physiology and Pharmacology
Shin SatoYuuka Mukai


Diabetic kidney disease is associated with oxidative stress, inflammation, and autophagy. The aim of this study was to investigate the effect of azuki bean (Vigna angularis) extract (ABE) on oxidative stress and autophagy in the kidneys of diabetic rats. Streptozotocin (STZ)-induced diabetic rats received 0, 10, or 40 mg/kg of ABE orally for 4 weeks, whereas vehicle-injected control rats received distilled water. Level of plasma glutathione and expression of heme oxygenase-1 (HO-1), p47phox (NADPH oxidase subunit), and markers associated with autophagy were examined. The glutathione level in the 40 mg/kg ABE-treated diabetic group (ABE-40 group) was higher than that of the untreated diabetic group (ABE-0 group). The HO-1 and p47phox protein expression levels of the ABE-40 group were lower (47% and 33%, respectively) than those of the ABE-0 group. The level of light chain 3B II (LC3B-II) was higher in the ABE-40 group than in the ABE-0 group. Protein levels of p62/sequestosome 1 (p62) in the ABE-40 group were lower than those in the ABE-0 group. Our results suggest that ABE may attenuate STZ-induced diabetic kidney injury by suppressing oxidative stress and (or) by upregulating autophagy.


Dec 2, 2000·Science·D J Klionsky, S D Emr
Jan 11, 2003·Free Radical Biology & Medicine·Irina G ObrosovaJaffar Nourooz-Zadeh
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Daisuke KoyaMasakazu Haneda
May 10, 2005·The Journal of Pharmacology and Experimental Therapeutics·Jing LiJohn Quilley
Nov 16, 2005·Pharmacology·Sameer SharmaKanwaljit Chopra
Jun 21, 2007·The Journal of Biological Chemistry·Serhiy PankivTerje Johansen
Nov 17, 2007·Genes & Development·Noboru Mizushima
May 31, 2008·Diabetes·Josephine M ForbesMark E Cooper
Jul 24, 2008·Journal of Clinical Biochemistry and Nutrition·Chizuko MaruyamaTeruichi Shimomitsu
Feb 11, 2010·Cell·Noboru MizushimaBeth Levine
Aug 24, 2010·Trends in Biochemical Sciences·Ruth Scherz-Shouval, Zvulun Elazar
Aug 19, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Francisca RodriguezMiguel G Salom
Nov 15, 2011·Cell·Noboru Mizushima, Masaaki Komatsu
Apr 17, 2012·Ageing Research Reviews·Kathrin Pallauf, Gerald Rimbach
Dec 7, 2013·PloS One·Donghai WenChuan-Ming Hao
Jun 4, 2014·Journal of Cellular and Molecular Medicine·Bo WangYu-xia Zhao
Jun 7, 2014·Biochimica Et Biophysica Acta·Luc RochetteCatherine Vergely
Sep 2, 2014·Current Medicinal Chemistry·S DraganR Timar
Jul 1, 2015·BMC Complementary and Alternative Medicine·Amal J FataniMohammed M Ahmed


Mar 16, 2017·Scientific Reports·Ji-Ye WangJian-Bing Wu
Dec 13, 2019·Journal of Diabetes Research·Yuyang WangPing Li
Jul 23, 2020·Journal of Diabetes Research·Dorin DragoșDorin Ionescu

Related Concepts

Vigna angularis
Programmed Cell Death, Type II
Streptozotocin Diabetes
Plant Extracts
Rats, Wistar
Oxidative Stress
Rats, Laboratory

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.