B- and T-cell responses in multiple sclerosis: novel approaches offer new insights

Journal of the Neurological Sciences
R HohlfeldKlaus Dornmair

Abstract

In experimental autoimmune encephalomyelitis (EAE), several target antigens of encephalitogenic T- and B-cell responses have been identified. However, in human multiple sclerosis (MS) the target antigens of pathogenic T and B cells have remained conjectural. Here we discuss how recent methodological advances have offered new insights into the nature of B- and T-cell receptor repertoires expressed in MS tissues, and how novel approaches have helped to identify neurofascin as a target of anti-axonal autoantibodies in MS and EAE.

References

Mar 4, 1998·Annals of Neurology·G P OwensD H Gilden
Nov 5, 1999·Science·T P ArstilaP Kourilsky
Jun 14, 2000·Annals of Neurology·J J ArchelosH P Hartung
Sep 6, 2001·The Journal of Experimental Medicine·E S HusebyJ Goverman
Apr 23, 2002·Nature Reviews. Neuroscience·Bernhard HemmerHans-Peter Hartung
Jun 28, 2002·Trends in Neurosciences·Harald NeumannHans Lassmann
Dec 13, 2002·Brain : a Journal of Neurology·Paolo A MuraroRoland Martin
Mar 12, 2003·Trends in Pharmacological Sciences·Oliver NeuhausHans-Peter Hartung
Aug 28, 2003·Lancet Neurology·Chris H Polman, Bernard M J Uitdehaag
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christian SkulinaNorbert Goebels
Aug 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Reinhard Hohlfeld, Hartmut Wekerle
Jun 25, 2005·Brain : a Journal of Neurology·Manuel A Friese, Lars Fugger
Sep 12, 2007·The Journal of Experimental Medicine·Emily K MatheyChristopher Linington
Sep 25, 2007·Brain : a Journal of Neurology·Andreas JunkerKlaus Dornmair
Oct 31, 2007·Annals of Neurology·Bernhard Hemmer, Hans-Peter Hartung

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Citations

Jun 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ashley S HarmsDavid G Standaert
Aug 13, 2015·Multiple Sclerosis and Related Disorders·David Baker, Sandra Amor
Jun 19, 2010·Progress in Neurobiology·Eilhard MixUwe K Zettl
Apr 17, 2016·Journal of the Neurological Sciences·O StichS Rauer
Apr 29, 2015·Autoimmunity Reviews·Tessa DhaezeNiels Hellings
Apr 11, 2012·Current Opinion in Neurology·Tobias Derfuss, Edgar Meinl
Apr 10, 2009·The Biochemical Journal·Lissa R HerronFrank J Gunn-Moore

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